Development of early diagnostic markers for aging-related peripheral neuropathy and novel anti-aging therapies.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590699
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Kumamoto University
• Principal Investigator: OBAYASHI KONEN 熊本大学, 大学院生命科学研究部, 教授 (90361899)
• Co-Investigator(Kenkyū-buntansha): ANDO Yukio 熊本大学, 大学院生命科学研究部, 教授 (20253742)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ニューロパチー / 加齢変化 / アンチエイジング

Outline of Final Research Achievements

In this study, we tried to develop early diagnostic markers for aging-related peripheral neuropathy and novel anti-aging therapies. Our results suggest that urinary liver-type fatty acid binding protein, quantitative sensory testing(QST), serum or urinary Glycer-glyceraldehyde-derived advanced glycation end product (Glycer-AGEs), small-fiber pain threshold values, and amount of the deposition of alpha-synuclein in peripheral nerves are the most useful methods to diagnose the aging-related peripheral neuropathy. Our present finding may have some implications for developing novel anti-aging therapies.

Free Research Field

病態検査学