Investigation of a role for multifunctional mechanosensor TRPV2 in adult sensory neuron and pain

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590725
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pain science
• Research Institution: Chubu University (2014); Nagoya University (2012-2013)
• Principal Investigator: KATANOSAKA Kimiaki 中部大学, 生命健康科学部, 准教授 (50335006)
• Co-Investigator(Renkei-kenkyūsha): TAGUCHI Toru 名古屋大学, 環境医学研究所, 助教 (90464156) ; KATANOSAKA Yuki 岡山大学, 大学院医歯薬学総合研究科, 助教 (60432639)
• Research Collaborator: NARUSE Keiji 岡山大学, 大学院医歯薬学総合研究科, 教授 ; TAKATSU Satomi 岡山大学, 大学院医歯薬学総合研究科, 博士研究員 ; MIZUMURA Kazue 中部大学, 生命健康科学部, 教授
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: TRPV2 / 疼痛 / 機械受容 / 侵害受容器 / 一次知覚神経 / 脊髄神経節

Outline of Final Research Achievements

In this research, we explored an unknown function of TRPV2, a nonselective cation channel, in adult primary sensory neurons by construction and analysis of a primary sensory neuron-specific conditional knock-out mice of TRPV2 (cKO). There was no apparent difference in number, population, and morphology of the primary sensory neurons, and their axonal development between the cKO mice and normal littermates. However, the nocifensive behavior of the mice against noxious mechanical stimuli and the incidence of stretch-sensitive primary sensory neurons with relatively high-thresholds were significantly reduced in cKO mice compared to the normal mice. These results suggest that TRPV2 in the adult primary sensory neurons is involved in the mechanical nociception.

Free Research Field

疼痛学