Validity assessment of DLco using portable equipment in health checks of indium-exposed workers.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590758
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene
• Research Institution: Keio University
• Principal Investigator: NAKANO Makiko 慶應義塾大学, 医学部, 講師 (70384906)
• Co-Investigator(Renkei-kenkyūsha): OMAE Kazuyuki 慶應義塾大学, 医学部, 教授 (60118924)
• Research Collaborator: TANAKA Akiyo 九州大学, 医学研究院, 講師 (10136484) ; HIRATA Miyuki 九州大学, 医学研究院, 助教 (30156674)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: インジウム / 肺機能 / 肺拡散能 / 胸部CT / 妥当性

Outline of Final Research Achievements

During the study period, we performed health checks on indium-exposed workers and measured diffuse lung capacity (DLco) as an effect marker of pulmonary function using a portable-type machine. After validity assessment of DLco with Quality Grade A-C (n=213), Spearman’s correlation coefficient was conducted between DLCO and scores of emphysematous change or interstitial change on High-Resolution CT (HRCT) (n=48). Correlation coefficients (r) were -0.320 (emphysematous change and DLco), -0.412 (emphysematous change and %DLco) and -0.386 (emphysematous change and %DLco/VA). The correlation between emphysematous change on HRCT and %DLco was higher than that between interstitial change on HRCT and %DLco. Results suggested that DLco, %DLco and %DLco/VA in indium-exposed workers were effective markers for emphysema.

Free Research Field

衛生学