Metabolic syndrome, its associated factors and mental health in occupational workers

2015 Fiscal Year Final Research Report

• Project/Area Number: 24590763
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene
• Research Institution: Nippon Medical School
• Principal Investigator: Kawada Tomoyuki 日本医科大学, 医学(系)研究科(研究院), 教授 (00224791)
• Co-Investigator(Kenkyū-buntansha): OTSUKA TOSHIAKI 日本医科大学, 医学部, 准教授 (80339374) ; INAGAKI HIROFUMI 日本医科大学, 医学部, 講師 (50213111) ; WAKAYAMA YOKO 日本医科大学, 医学部, 講師 (40104062) ; KATSUMATA MASAO 日本医科大学, 医学部, 助教 (80169482)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: メンタルヘルス / メタボリックシンドローム / 職場労働者 / インスリン抵抗性 / 生活習慣 / 発症率 / 予防

Outline of Final Research Achievements

Male workers, aged from 35 to 60 years old, were recruited in this study to know the association between mental health and metabolic syndrome (MetS). Cross-sectional and one-year follow-up studies were set for the analysis. The number of participants was 3,639 people without MetS-related disease. Mental status was evaluated by General Health Questionnaire 12-item version (GHQ12), and serum insulin and serum high sensitive C-reactive protein (CRP) were used as biological markers. Logistic regression analysis was mainly used for the analysis. Prevalence rate of MetS was 16.4% in the cross-sectional study, and the associated factors with MetS were serum insulin, serum high sensitivity CRP, age and GHQ12. One-year follow-up study for incident MetS was also conducted and the incidence rate was 8.8%. Predictors for MetS were age, serum uric acid, serum ALT, serum high sensitivity CRP and a marker of insulin resistance. In addition, regular exercise was a protective factor for incident MetS.

Free Research Field

予防医学