2014 Fiscal Year Final Research Report
Worksite-based epidemiological study on the relationship between methylarginine derivatives and the risk of metabolic syndrome.
| Project/Area Number |
24590765
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NISHIYAMA Yasuhiro 日本医科大学, 医学部, 助教 (20350077)
INAGAKI Hirofumi 日本医科大学, 医学部, 講師 (50213111)
KAWADA Tomoyuki 日本医科大学, 大学院医学研究科, 教授 (00224791)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 非対称性ジメチルアルギニン / メタボリック症候群 / 疫学研究 / 脳卒中 / 高血圧 / 高コレステロール血症 |
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| Outline of Final Research Achievements |
We measured serum asymmetric dimethylarginine (ADMA) levels in male workers who underwent annual health examination. The ADMA levels were associated with age and several lifestyle-related diseases such as blood pressure and lipid profiles, as well as the predicted risk of stroke. However, the ADMA levels did not predict the future onset of the metabolic syndrome. The administration of cholesterol-lowering drug reduced the risk of incident hypertension in patients with hypercholesterolemia.
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| Free Research Field |
予防医学
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