To detect the environmental risk factors relating to developmental disorder in school-children and prevention used nested case-control study.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590777
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Hokkaido University
• Principal Investigator: IKENO Tamkio 北海道大学, 環境健康科学研究教育センター, 特任講師 (80569715)
• Co-Investigator(Kenkyū-buntansha): MUROHASHI Harumitsu 北海道大学, 大学院教育学研究院, 教授 (00182147) ; SHIRAISHI Hideaki 北海道大学, 北海道大学病院, 助教 (80374411) ; SASAKI Seiko 北海道大学, 大学院医学研究院, 助教 (30448831)
• Co-Investigator(Renkei-kenkyūsha): KISHI Reiko 北海道大学, 環境健康科学研究教育センター, 特任教授 (80112449) ; ARAKI Atsuko 北海道大学, 環境健康科学研究教育センター, 准教授 (00619885) ; AZUMI Kaoru 北海道大学, 北海道大学病院, 特任講師 (90221720)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 発達障害 / ADHD / 学童期 / 喫煙曝露 / 環境遺伝交互作用

Outline of Final Research Achievements

In this study, we examined the effects of environmental factors on risk of attention hyperactivity diorder (ADHD) in a prospective birth cohort with more than 20,000 participants. 1)We assessed the effects of smoking exposure during pregnancy and at age 7 years old, using ADHD rating scale (ADHD-RS). We found that home environment and maternal depression have more effects on ADHD-RD than smoking exposure. 2)We determined IQ of 179 children using WISC-IV test in a nested case -control study. 3) We investigated single nucleotide polymorphisms(SNPs) of neurotransmitter related gene （DRD4,DAT1,HTR1B,COMT,SNAP25）and brain-derived neurotrophic factor （BDNF）by EP1 system (Fludigm)in ADHD-suspected and control groups. We have finished SNPs determination in 200 subjects of 390 statistical power.

Free Research Field

医歯薬学