Epidemiological Study on the Association of Obesity-Related and Diabetes-Related Genes with Colorectal Adenoma

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590830
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: National Cancer Center Japan
• Principal Investigator: YAMAJI Taiki 独立行政法人国立がん研究センター, がん予防・検診研究センター, 室長 (10466203)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 大腸腺腫 / 肥満関連遺伝子 / 糖尿病関連遺伝子 / 分子疫学研究

Outline of Final Research Achievements

Supported by Grant-in-Aid for Scientific Research C, this researcher conducted an epidemiological study on the association of obesity-related and diabetes-related genes with colorectal adenoma. No association was observed for 9 single nucleotide polymorphisms selected form one obesity-related gene (FTO) and two diabetes-related genes (TCF7L2 and KCNQ1) in relation to colorectal adenoma. These results should be interpreted in light of several limitations of the study, and further studies are needed to confirm the findings of this study.

Free Research Field

がん疫学