Seroprevalence of HBV and Treponema pallidum in HIV-positive individuals and analysis of HBV genotype

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590840
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Osaka Prefectural Institute of Public Health
• Principal Investigator: KOJIMA Yoko 大阪府立公衆衛生研究所, その他部局等, 研究員 (70291218)
• Co-Investigator(Kenkyū-buntansha): KAWAHATA Takuya 大阪府立公衆衛生研究所, ウイルス課, 主任研究員 (80270768) ; MORI Haruyo 大阪府立公衆衛生研究所, ウイルス課, 主任研究員 (20250300)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: HIV / HBV / 梅毒トレポネーマ / 感染歴 / HBVジェノタイプ

Outline of Final Research Achievements

This research determined the prevalence of HIV, HBV and Treponema pallidum (TP) in populations who visited primary sexually transmitted infection (STI) clinics in Osaka province. Compared with HIV-negative groups, the HBs antigen-positive rate and the seroprevalence of HBV among HIV positive-individuals were significantly higher (P<0.001). Genetic analysis revealed that 17 of 23 (74%) HBV isolates detected in HIV co-infected cases were the foreign genotypes of Ae and G, including three of Ae/G recombinant viruses. From these results, it is highly recommended for clinicians to consider HIV testing when a patient attending a primary STI clinic is positive for HBs antigen, especially in case it is a foreign genotype HBV. The rate of TP antibody positivity was not significantly different between HIV-positive and HIV-negative groups during 2006-2014.

Free Research Field

ウイルス学