Diagnosis of Drug Induced arrhythmia

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590858
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Legal medicine
• Research Institution: Nagasaki University
• Principal Investigator: IKEMATSU Kazuya 長崎大学, 医歯薬学総合研究科(医学系), 教授 (80332857)
• Co-Investigator(Kenkyū-buntansha): TUBOI Takashi 東京大学, 総合文化研究科, 准教授 (80415231)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 薬剤 / 突然死 / 心筋症 / マウス

Outline of Final Research Achievements

Long treatment of anti-psycotic drug sometimes induces sudden cardiac death, however, forensic pathologists hardly find any findings. We examined the gene expressional profile with microarray analysis for chronic chlorpromazine treatment of mouse. The results showed that arrhythmia and cardiac myopathy might induce. Chlorpromazine treatment resulted in chromatin aggregation in nuclear on mouse heart tissue and cultural cell, and the treatment showed positive signal Tunel method. This strongly suggested that chronic chlorpromazine treatment might induce apoptosis in heart tissue and cell. Additionally, in human heart, the results were the same.
Therefore, chronic chlorpromazine treatment might induce cardiomyopathy and followed sudden cardiac death.

Free Research Field

法医病理学