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2014 Fiscal Year Final Research Report

An automated on-line method for simultaneous analysis of drugs by high-performance liquid chromatography/mass spectrometry with backflush column switching

Research Project

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Project/Area Number 24590870
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Legal medicine
Research InstitutionAichi Medical University

Principal Investigator

ARINOBU Tetsuya  愛知医科大学, 医学部, 准教授 (30329776)

Project Period (FY) 2012-04-01 – 2015-03-31
Keywords法中毒学 / 分析化学
Outline of Final Research Achievements

Existing methods for the detection of the drugs in biological samples usually involve time-consuming multi-step pretreatment. To avoid such sample pretreatments, special HPLC columns, which enabled direct injection of crude biological samples, were developed; we applied them to compounds of forensic toxicological interest. In this study, we have established an automated on-line method for ultra-fast determination of haloperidol and its metabolites, which is widely used as an antipsychotic drug and frequently encountered in the fields of forensic and clinical toxicology, in biological samples, by HPLC-MS/MS with backflush column-switching using one of special HPLC columns and a monolithic separation column.

Free Research Field

法中毒学

URL: 

Published: 2016-06-03  

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