Therapeutic basis for sarcopenia control mediated by nuclear receptors

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590876
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: The University of Tokyo
• Principal Investigator: OGAWA SUMITO 東京大学, 医学部附属病院, 准教授 (20323579)
• Co-Investigator(Kenkyū-buntansha): OTA Hidetka 東京大学, 医学部附属病院, 特任講師 (20431869)
• Co-Investigator(Renkei-kenkyūsha): AKISHITA Masahiro 東京大学, 医学部附属病院, 教授 (00261975)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ビタミンD

Outline of Final Research Achievements

In this study, therapeutic basis for age-related sarcopenia control mediated by nuclear receptor ligand including vitamin D was investigated in vitro and in vivo, based on quantitative PCR and body composition analyses, respectively. It was suggested that vitamin D and leucine metabolite exert inflammatory control and improve skeletal muscle property, suggesting that nuclear receptor-mediated transcriptional control including vitamin D receptor might be effective for prevention and therapy of sarcopenia.

Free Research Field

医歯薬学