New strategy for blood pressure management with detection of inappropriate blood pressure variability in the elderly: Development of useful cuff-less 'Wearable blood pressure sensor'

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590878
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: The University of Tokyo
• Principal Investigator: IIJIMA KATSUYA 東京大学, 高齢社会総合研究機構, 准教授 (00334384)
• Co-Investigator(Kenkyū-buntansha): 大田 秀隆 東京大学, 医学部附属病院, 助教 (20431869) ; 柴崎 孝二 東京大学, 高齢社会総合研究機構, 特任研究員 (20625735)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 血圧変動 / 動脈壁硬化 / ウェアラブル血圧センシング / 動脈石灰化 / ex vivo新実験モデル構築 / 被災地 / 血圧遠隔管理システム

Outline of Final Research Achievements

<Research No.1> After East Japan earthquake, the remote control system of blood pressure (BP) in elderly evacuees in Kamaishi city was conducted. This challenging system could reflect inadequate BP variability (BPV) quickly and accurately and may give them additional effects on awareness to health promotion and homebound prevention.
<Research No.2> We developed wearable continuous BP monitoring sensor without a cuff-stress in the elderly. This device might approach to the potential to achieve the quality-up of treatment strategy with consideration for very short-term BPV.
< Research No.3> We established the great experimental model of vascular calcification (VC) using organ culture of aorta. Aortas were dissected from mice and cultured with inorganic phosphate to induce VC. This organ culture ex-vivo model of VC can achieve to assess morphometric and phenotypic changes and so on. It suggests that this model will be useful to explore the molecular mechanisms of VC and senescent pathology.

Free Research Field

老年医学