2014 Fiscal Year Final Research Report
Exploratory Research for crude drugs having activated platelet-mediated inhibiting effect on diabetic microangiopathy
| Project/Area Number |
24590880
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | University of Toyama |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 生薬 / 糖尿病性細小血管症 / 血小板マイクロパーティクル / 活性型血小板 / 牛膝 / 紅花 / 丹参 |
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| Outline of Final Research Achievements |
To evaluate the inhibiting effects of crude drugs (anti-blood stasis drug) on activated platelets and/or platelet-derived microparticles (PDMP), which assume key roles on the onset and development of diabetic microangiopathy. The extracts of Achyranthis Radix, Danshen Root, and Carthami Flos were orally administered to streptozotocin-induced diabetes rats for day after day forcibly. After seven days, activated platelets and PDMP were measured by FACS and ELISA. Although the extracts of three crude drugs have no effect on activated platelets, elevated PDMP, induced by hyperglycemia, were decreased by these extracts. The result of the inhibiting effect on PDMP suggested that the extracts of Achyranthis Radix, Danshen Root, and Carthami Flos might be useful on the inhibition of the onset and development of diabetic microangiopathy.
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| Free Research Field |
漢方医学
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