2014 Fiscal Year Final Research Report
Analysis of accumulation of amyloid beta with D678N APP mutation
| Project/Area Number |
24590885
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Tottori University |
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Principal Investigator |
WADA Kenji 鳥取大学, 医学部附属病院, 講師 (60346351)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | アルツハイマー病 / アミロイドβ / アミロイド前駆体蛋白 / 遺伝子変異 / 神経変性 |
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| Outline of Final Research Achievements |
We planned the biochemical and neuropathological examination of the human brain derived from the patients of familial Alzheimer disease with a novel missense mutation, Asp678Asn (D678N), in the amyloid precursor protein (APP) gene. This mutation, located at the sixth amino acid of amyloid (Aβ) is assumed to have distinct effect on Aβ aggregation or their influence on the physiological and pathological roles of APP. We produced novel antibodies which specifically recognized this novel amyloid β
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| Free Research Field |
神経内科
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