Characterization of inflammageing in progeroid "Werner syndrome"

2015 Fiscal Year Final Research Report

• Project/Area Number: 24590902
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: Goto Makoto 東京女子医科大学, 医学部, その他 (00170465)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 炎症老化 / 炎症 / 老化 / サイトカイン / CRP / ウエルナー症候群 / ケモカイン / 早老症

Outline of Final Research Achievements

Minor-inflammation driven ”Inflammageing"　was investigated by using 26-cytokine multiplex assay system in the sera from healthy volunteers aged between 0 and 100 and 41 patients with mutation-proven Werner syndrome.
TH2 cytokine levels including IL-4, 6, 13, 15 and GM-CSF were significantly elevated with healthy ageing. In the patients with Werner syndrome, TH2 cytokine levels including IL-4, 6, 10 and GM-CSF were significantly elevated compared with age sex-matched healthy counterpart, although age-associated elevation of TH2 cytokines was not observed.
Inflammageing may be a common deriving force to accelerate ageing both in healthy ageing and Werner syndrome.

Free Research Field

老化学、免疫学