2014 Fiscal Year Final Research Report
Role of Duodenal Iron Transporters in Cardio-Renal Anemia Syndrome
Project/Area Number |
24590907
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General internal medicine (including Psychosomatic medicine)
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Research Institution | Hyogo Medical University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
NAITO Yoshiro 兵庫医科大学, 医学部, 講師 (10446049)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Keywords | 循環器 / 心不全 / 腎不全 / 貧血 / 鉄代謝調節機構 / 鉄 / エリスロポエチン / 心腎貧血連関 |
Outline of Final Research Achievements |
We found the impaired expression of duodenal iron transporters in heart failure (HF) and chronic kidney disease (CKD) model rats. Duodenal expression of crucial iron transporters, such as duodenal cytochrome b and divalent metal transporter 1 was not increased in both HF and CKD model rats despite being under iron-deficient conditions. As a result, our data suggests that impaired intestinal iron absorption may be a novel therapeutic target in cardio-renal anemia syndrome.
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Free Research Field |
医歯薬学
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