Role of Duodenal Iron Transporters in Cardio-Renal Anemia Syndrome

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590907
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Hyogo Medical University
• Principal Investigator: MASUYAMA Tohru 兵庫医科大学, 医学部, 教授 (70273670)
• Co-Investigator(Kenkyū-buntansha): NAITO Yoshiro 兵庫医科大学, 医学部, 講師 (10446049)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 循環器 / 心不全 / 腎不全 / 貧血 / 鉄代謝調節機構 / 鉄 / エリスロポエチン / 心腎貧血連関

Outline of Final Research Achievements

We found the impaired expression of duodenal iron transporters in heart failure (HF) and chronic kidney disease (CKD) model rats. Duodenal expression of crucial iron transporters, such as duodenal cytochrome b and divalent metal transporter 1 was not increased in both HF and CKD model rats despite being under iron-deficient conditions. As a result, our data suggests that impaired intestinal iron absorption may be a novel therapeutic target in cardio-renal anemia syndrome.

Free Research Field

医歯薬学