A study to explore functional biomarkers for early Alzheimer's disease using MEG and amyloid-PET

2015 Fiscal Year Final Research Report

• Project/Area Number: 24590908
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: National Center for Geriatrics and Gerontology
• Principal Investigator: NAKAMURA Akinori 国立研究開発法人国立長寿医療研究センター, 脳機能画像診断開発部, 室長 (00237380)
• Co-Investigator(Kenkyū-buntansha): KATO Takashi 国立研究開発法人国立長寿医療研究センター, 脳機能画像開発研究部, 室長 (60242864) ; ARAHATA Yutaka 国立研究開発法人国立長寿医療研究センター, 脳機能診療部, 医長 (80501212)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: アルツハイマー病 / 脳磁図 / アミロイドイメージング / 早期診断

Outline of Final Research Achievements

Magnetoencephalography (MEG) can detect brain network and synaptic functions very sensitively. The objective of this study, using MEG and amyloid-PET imaging, was to develop functional biomarkers for Alzheimer’s disease (AD) which are useful in the early stages of AD. We found two possible MEG biomarkers as follows: 1) Using somatosensory evoked magnetic field recovery function to paired electric stimuli, the cortical excitability associated with local amyloid deposition can be evaluated. 2) Functional network alterations in asymptomatic elders at risk for AD (amyloid-positive cognitively normal elders) could be detected by assessing functional connectivity of resting-state MEG signals.

Free Research Field

認知症　画像診断