2014 Fiscal Year Final Research Report
Analysis of the role of FGF10 in the stem cell niche of gastric carcinogenesis
| Project/Area Number |
24590911
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Gifu University |
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Principal Investigator |
TOMITA HIROYUKI 岐阜大学, 医学(系)研究科(研究院), 准教授 (50509510)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 増殖因子 |
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| Outline of Final Research Achievements |
We have found that expression of FGF10 is associated with gastric cancer in humans. FGF10 expression has an important role in gastric carcinoma, which makes a small tubular shape. Further, we have made FGF10 inducible transgenic ES cells and mice. Interestingly, we have found that FGF10-inducible mice develop hyperplasia in the stomach but not tumors.
However, continuous induction of Fgf10, in particular, at low level, is associated with the development of the intraepithelial papillary neoplasms of bile duct.
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| Free Research Field |
腫瘍学
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