Therapeutic strategy against gastrointestinal cancers targeting nardilysin

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590914
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kyoto University
• Principal Investigator: KOMEKADO Hideyuki 京都大学, 医学(系)研究科(研究院), 非常勤講師 (90452359)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 癌

Outline of Final Research Achievements

In this study, we aimed to investigate the effect of nardilysin (NRDc) on gastric or colorectal cancer and to examine the possibility of novel therapeutic strategy targeting NRDc. Knockdown of NRDc suppressed cancer cell growth concomitantly with decreased secretion of inflammatory cytokines, enhanced interferon-response, and impaired cell cycle progression. Knockdown of NRDc also lead enhanced apoptosis and attenuated growth of gastric or colorectal cancer cells when treated with anti-cancer agents. Furthermore, anti-NRDc neutralizing antibody suppressed cancer cell growth. Thus, we demonstrated the role of NRDc during cancer development and obtained the clue to achieve novel therapeutic strategies against gastric or colorectal cancer.

Free Research Field

消化器内科学