Research on the mechanism of acetaldehyde related esophageal carcinogenesis and clinical application for prevention

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590917
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kyoto University
• Principal Investigator: MUTO Manabu 京都大学, 医学(系)研究科(研究院), 教授 (40360698)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 癌 / 臨床 / アルコール

Outline of Final Research Achievements

In this study, we revealed that acetaldehyde exposure in vitro causes acetaldehyde derived DNA adducts formation in the esophageal squamous epithelium, phosphorylation of p53 protein and cellular senescence. In human, the extent of DNA damage induced by acetaldehyde exposure was also correlated with the degree of change in the esophageal precancerous dysplasia. Inhibition of ALDH2 expression by siRNA increased DNA damage. Long-term exposure of acetaldehyde to the esophageal squamous epithelium in vitro affected esophageal squamous differentiation (keratinization), and caused confusion of polarity of nuclei of basal or parabasal cell, ballooning and parakeratotic changes, it was similar to the dysplastic squamous epithelium.

Free Research Field

臨床腫瘍学