Surrogate marker for sleep disturbances in gastrointestinal diseases

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590925
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Osaka City University
• Principal Investigator: FUJIWARA YASUHIRO 大阪市立大学, 医学(系)研究科(研究院), 准教授 (40285292)
• Co-Investigator(Kenkyū-buntansha): TOMINAGA Kazunari 大阪市立大学, 大学院医学研究科, 准教授 (80336768) ; WATANABE Toshio 大阪市立大学, 大学院医学研究科, 准教授 (50336773) ; TANIGAWA Tetsuya 大阪市立大学, 大学院医学研究科, 講師 (70423879)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 睡眠障害 / 逆流性食道炎 / マイクロRNA

Outline of Final Research Achievements

Sleep condition in rats was assessed by electroencephalography using a chronic acid reflux esophagitis model. Wake periods significantly increased in rats with reflux esophagitis compared with control while NREM periods significantly decreased. An increase in short NREM bouts and a decrease in long NREM bouts as well as a decrease in delta power density in rats with reflux esophagitis suggested the presence of sleep fragmentation and poor sleep quality in rats with reflux esophagitis. Such sleep disturbances were improved by the treatment with proton pump inhibitors. Microarray analysis using miRNA in serum exosome showed increased expression of six miRNAs and decreased expression of five miRNAs in rats with reflux esophagitis compared with control.

Free Research Field

医歯薬学