2015 Fiscal Year Final Research Report
The expresssion of microRNA in the intestinal metaplasia and gastric carcinoma
| Project/Area Number |
24590926
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | microRNA / intestinal metaplasia / Cdx2 |
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| Outline of Final Research Achievements |
Cdx2-transgenic mouse is the model mouse of the intestinal metaplasia related to gastric carcinoma. The expressions of microRNA in the intestinal metaplasia of Cdx2-transgenic mouse stomach were analyzed. microRNA-21, microRNA-137, and microRNA-145 were elevated in the intestinal metaplasia and gastric carcinoma of Cdx2-transgenic mouse stomach. microRNA-21 downregulated the expression of PTEN, microRNA-137 downregulated the expression of Musashi1. microRNA-145 downregulated the expression of Oct3/4, Sox2, and KLF4.
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| Free Research Field |
消化器内科
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