2014 Fiscal Year Final Research Report
The analysis for the regulation of IEC differentiation by the switching mechanism of GSK3
| Project/Area Number |
24590935
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
TSUCHIYA Kiichiro 東京医科歯科大学, 医歯(薬)学総合研究科, 寄附講座准教授 (40376786)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Mamoru 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (10175127)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | Atoh1 / GSK3 / TNFα / 蛋白安定機構 |
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| Outline of Final Research Achievements |
We have clarified that β-catenin and Atoh1 regulated by GSK-3βcontrol not only cell differentiation and proliferation but also cell fate under various kinds of cell signaling to change the target protein of GSK-3β. In this study, we aimed to identify the adapter protein which is specific for GSK3-Atoh1 complex and understand GSK3 control structure in each signal via GSK3. Finally we aimed to elucidate the differentiation system of the intestinal epithelia cell.
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| Free Research Field |
消化器病学
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