Analysis of plasma exosome containing micro RNA in gastrointestinal cancer

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590944
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kyushu University
• Principal Investigator: BABA Eishi 九州大学, 医学(系)研究科(研究院), 教授 (00315475)
• Co-Investigator(Kenkyū-buntansha): NIIRO Hiroaki 九州大学, 大学病院, 准教授 (20380636) ; AKASHI Koichi 九州大学, 大学院医学研究院, 教授 (80380385)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 消化器がん / がん幹細胞 / エクソゾーム / 微小環境 / 可溶性因子

Outline of Final Research Achievements

Human gastrointestinal tumor has cancer stem cell (CSC) population, which possess self-renewing potential. The present study revealed the stemness in the EpCAM-high and CD44-positive human colorectal cancer cells. Only these cells efficiently form sphere in vitro. Soluble factors including exosomes may play an important role in the interaction between colorectal CSCs and the cells forming microenvironment. The present study suggested that these interactions might possibly induce of stemness in non-CSCs.

Free Research Field

消化器がん、腫瘍内科