2015 Fiscal Year Final Research Report
Analysis of Regulatory B cell Distribution and Function in Primary Biliary Cirrhosis (Cholangitis) Model Mice and Optimization of B cell Targeted Therapy
| Project/Area Number |
24590952
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Akita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
CHIHARA Junichi (80197615)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 原発性胆汁性肝硬変(原発性胆汁性胆管炎) / B細胞 / IL-10 |
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| Outline of Final Research Achievements |
We have conducted a model mice study of human Primary Biliary Cirrhosis (Cholangitis) to propose a highly effective and safe therapeutic strategy using regulatory B cells. In order to identify and analyze regulatory B cells that produce Interleukin (IL)-10, one of the immunosuppressive cytokines, IL-10-GFP reporter mice were crossed with the model mice of Primary Biliary Cirrhosis (Cholangitis) to develop IL-10-GFP expressing model mice. The developed model mice demonstrated liver inflammation histopathologically, serum positivity of anti-mitochondrial autoantibody, and elevated levels of total IgA and IgG, which were equivalent to those found in the original model mice. In addition, it was revealed that distribution of IL-10 producing regulatory B cells differ extremely among the physical areas.
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| Free Research Field |
医歯薬学（消化器内科学）
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