2016 Fiscal Year Final Research Report
The role of nuclear receptor CAR in the liver regeneration and repair madiated by oval cell proliferation.
| Project/Area Number |
24590954
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHINARI Kouichi 静岡県立大学, 大学院薬学系研究科, 教授 (60343399)
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| Research Collaborator |
TOJIMA Hiroki 群馬大学, 大学院医学系研究科, 大学院生
TAHARA Hiroki 群馬大学, 大学院医学系研究科, 大学院生
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| Project Period (FY) |
2012-04-01 – 2017-03-31
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| Keywords | 核内受容体CAR / オーバル細胞増殖 / 肝前駆細胞 / 肝再生 |
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| Outline of Final Research Achievements |
We have demonstrated that choline-deficient DL-ethionine supplemented (CDE) diet activates the nuclear receptor constitutive active/androstane receptor (CAR), resulting in proliferation of oval cells in mouse liver. Activation of CAR by CDE was shown by cytochrome P450 (CYP)2B10 and DNA damage-induced protein 45 family (GADD45)β mRNA induction after feeding a CDE diet to Car+/+ mice.Unlike 3,5-diethoxycarbonyl-1,4-dihydrocollidine containing diet, the liver damage, and oval cell proliferation were found in both Car+/+ and Car-/- mice after feeding a CDE diet.There was no significant difference of the EpCAM positive cells containing bile duct epithelial cells and liver progenitor cells between the Car+/+ and Car-/- mice as a result of immunostaining analysis
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| Free Research Field |
肝臓病学
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