Involvement of androgen receptor and unfolded protein response in human liver and pancreatic cancers

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590955
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Chiba University
• Principal Investigator: KANDA TATSUO 千葉大学, 医学(系)研究科(研究院), 講師 (20345002)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: アンドロジェンレセプター / 小胞体ストレス / 自然免疫 / 肝細胞癌 / 膵癌 / C型肝炎ウイルス / GRP78 / アポトーシス

Outline of Final Research Achievements

(1) Endoplasmic reticulum (ER) stress response plays a key role in hepatic cell damage induced by an innate immune response. (2) Androgen receptor (AR) and ER-stress response are cooperatively involved in human liver cancer, one of the male-dominant cancers. (3) Hepatitis C virus (HCV) infection enhances GRP78 expression, which confers to the resistance against apoptosis in HCV-infected hepatocytes. (4) ER stress response plays an important role in pancreatic cancer cell line KP-2, in which AR highly expresses.

Free Research Field

医歯学