2014 Fiscal Year Final Research Report
Development of the treatment strategy for HCV-related diseases using ultra-deep sequencing technology.
| Project/Area Number |
24590965
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ENOMOTO Nobuyuki 山梨大学, 総合研究部, 教授 (20251530)
MIURA Mika 山梨大学, 総合研究部, 助教 (00436875)
KOMATSU Nobutoshi 山梨大学, 総合研究部, 助教 (50568003)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | HCV / Ultra-deep sequence / DAA / 耐性変異 / Quasispecies / 系統樹 |
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| Outline of Final Research Achievements |
It has been hard to predict the treatment response of HCV-infected patients to the most advanced DAA-included therapy. Using ultra-deep sequencing technology coupled with phylogenetic analysis, this study was conducted to disclose the role of viral quasispecies in determining the treatment response to DAA-included anti-HCV therapy. As a result, it was disclosed that viral quasispecies changed dynamically and certain viral isolates were selected with the introduction of DAA-based therapy. The result of the study provides better understanding of the mechanism in the appearance of DAA resistance.
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| Free Research Field |
肝臓病学
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