Regulation of liver innate immunnity in human hepatocellular carcinoma

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590973
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Osaka University
• Principal Investigator: TATSUMI Tomohide 大阪大学, 医学(系)研究科(研究院), 助教 (20397699)
• Co-Investigator(Kenkyū-buntansha): MIYAGI Takuya 大阪大学, 大学院医学系研究科, 助教 (80532986)
• Research Collaborator: NAWA Takatoshi ; AONO Satoshi
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 肝細胞癌 / C型肝炎ウイルス / 抗癌剤 / 先天免疫 / 細胞周期

Outline of Final Research Achievements

The aim of this study is to investigate the cell death of hepatitis C virus (HCV) infected hepatocellular carcinoma (HCC) cells. HCV-infected HCC cells were more resistant to epirubicin and sorafenib than non-infected HCC cells. HCV-infected HCC cells exhibited anti-apoptotic and higher expression of ATP-binding cassette drug transporters. HCV infection resulted in increasing the characteristics of cancer stem cell of HCC. Cell cycle analysis revealed the increase of sub-population of G0/G1 phase in HCV-infected HCC cells. HCV eradication by interferon-alpha treatment resulted in improvement of the efficacy of anti-cancer drug by changing the anti-apoptotic characteristics. These results suggested that eradication of HCV should be required in the treatment of HCC.

Free Research Field

消化器内科学