Basic study of the cell cycle related molecules affiliated with liver regeneration and clinical application

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590984
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kumamoto University
• Principal Investigator: NAGAHAMA Hiroyasu 熊本大学, 医学部附属病院, 非常勤診療医師 (60381000)
• Co-Investigator(Kenkyū-buntansha): SASAKI Yutaka 熊本大学, 生命科学研究部, 教授 (70235282) ; TANAKA Motohiko 熊本大学, 生命科学研究部, 准教授 (20346985) ; NAOE Hideaki 熊本大学, 医学部附属病院, 助教 (30599246) ; WATANABE Takehisa 熊本大学, 生命科学研究部, 助教 (20634843)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 肝再生 / ﾄﾗﾝｽｸﾘﾌﾟﾄｰﾑ / 細胞周期

Outline of Final Research Achievements

p27Kip1 is a key molecule of the cell cycle regulation in hepatocyte. The depression of p27kip1 cause liver hypertrophy. Therefore, we consider the elucidation of the regulatory mechanism of Kip1 lead to regenerative medicine for the severe liver disease. We examine how the molecule effects on the cell proliferation by using primary hepatocyte delivered from p27Kip1 KO mouse and hepatic cell line. As a results, the responsible molecule was not isolated with in the specified period, though we extract the some candidates, such as the related molecule of estrogen.

Free Research Field

肝再生、細胞周期、消化器病学