2014 Fiscal Year Final Research Report
Analysis of relation between oxidative DNA repair genes,MUTYH and hepatocarcinogenesis
| Project/Area Number |
24590985
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
JUNJI Kato 札幌医科大学, 医学部, 教授 (20244345)
田中 信悟 札幌医科大学, 医学部, 研究員 (60564024)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 肝発癌危険因子 / 肝癌予防 / 酸化的DNA損傷 / 肝癌診断 |
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| Outline of Final Research Achievements |
In one of MutYH SNPs (s3219487), the frequency of minor homo or hetero allele carrier in the HCC group significantly higher than that in HCC group. In addition, the expression of MUTYH mRNA in minor homo allele tended to be lower than that in major homo allele. Multivariate Cox regression analysis indicated that Age and the minor allele of this SNP in MUTYH factors were significantly associated with hepatocarcinogenesis independently. These results indicated that the minor hetero allele of this SNP in MUTYH could be a significant risk factor of liver carcinogenesis from CHC and could be a predictive marker of HCC development in CHC patients.
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| Free Research Field |
消化器内科学
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