Role of IFN-Lambda for chronic hepatitis C treatment toward personalized medicine

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590988
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Nagoya City University
• Principal Investigator: WATANABE Tsunamasa 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (20338528)
• Co-Investigator(Kenkyū-buntansha): SUGAUCHI Fuminaka 名古屋市立大学, 大学院医学研究科, 研究員 (23590982)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: C型肝炎ウイルス / 遺伝子多型 / IL28B / インターフェロン誘導遺伝子 / 自然免疫応答 / IFNλ / PEG-IFNα治療 / PEG-IFNλ治療

Outline of Final Research Achievements

To analyze the effects of interferon (IFN)-λ, which has received considerable attention in hepatitis C virus (HCV), the induction of antiviral IFN-stimulated genes (ISGs) was investigated using chronically HCV infected model mice. IFN-λ expression levels by treatment of peg-IFN-α and peg-IFN-λ were significantly induced in HCV-infected human hepatocytes harbouring the favourable IL28B genotype. Moreover, IFN-λ responses against 5’-triphosphate single stranded RNA transfection (mimic of HCV infection) were varied from the host polymorphisms near IL28B. Our results suggest that a response of human hepatocytes against HCV infection could be contribute to type III IFN production and the responses might be depended on the genetic feature near IL28B.

Free Research Field

肝臓病学