Analysis of dysregulated lipid and iron metabolisms in patients with nonalcoholic fatty liver disease

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590990
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: MITSUYOSHI Hironori 京都府立医科大学, 医学(系)研究科(研究院), 講師 (30363972)
• Co-Investigator(Kenkyū-buntansha): YASUI Kohichiroh 京都府立医科大学, 医学研究科, 准教授 (30323695)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 非アルコール性脂肪性肝疾患

Outline of Final Research Achievements

Relationships between single nucleotide polymorphisms (SNPs) of GP120 or ferroportin and NAFLD development were examined. However, no significant relationship was identified. Now, prospective studies on SNP of adiponutrin in NAFLD patients are ongoing. Subsequently, the role of inflammasomes for the pathogenesis of NAFLD was examined. The expression of NLRP3 infalmassome-related molecules was increased in the liver of NAFLD. IL-1β and IL-18 produced by NLRP3 activation in hepatic macrophages and Kupffer cells were associated with histological inflammation or serum transaminases.

Free Research Field

肝臓病学