2014 Fiscal Year Final Research Report
O-glycosylation by GalNAc-T3 in pancreatic cancer
| Project/Area Number |
24591013
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kochi University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HONKE Koichi 高知大学, 教育研究部医療学系, 教授 (80190263)
KOTANI Norihiro 埼玉医科大学, 医学部・生化学講座, 准教授 (90342782)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 膵臓学 / O結合型糖鎖 / 膵臓がん / 細胞増殖 |
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| Outline of Final Research Achievements |
This project seeks to identify the formation of uncommon structure of glycoforms catalyzed by one of GalNAc-transferases GalNAcT-3 on the target glycoprotein GNAT1. The data provided here could provide important information to aid to improve the clinical outcome of pancreatic cancer patients. We determined the O-glycosylation sites and carbohydrate alterations on GNAT1 in pancreatic cancer cells. Furthermore, GNAT1-bound proteins were identified and these complexes were associated with cell proliferation in pancreatic cancer cells. These discovery based studies will provide insight into the manner in which GalNAcT-3 acts on the specific substrate proteins that are important to growth/survival of pancreatic cancer cells and contributes to disease process in epigenetic manner (formation of uncommon structure of glycoforms) that is based on its substrate specificities.
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| Free Research Field |
消化器内科学
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