2014 Fiscal Year Final Research Report
Application of inhibitory method of pancreatic cancer cell growth by the regulation of lumican glycosylation using therapeutic peptides.
| Project/Area Number |
24591019
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kinki University (2013-2014)
Nippon Medical School (2012) |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 膵臓癌 / ルミカン / プロテオグリカン / プロテオミクス / アポトーシス |
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| Outline of Final Research Achievements |
It has been reported that lumican expression level showed positive correlation with cell growth of pancreatic ductal adenocarcinoma (PDAC) cells and showed negative correlation with cell invasion of PDAC cells. In this study, we performed global shotgun proteomic analysis using lumican-regulated PANC-1 cells to examine the effect of lumican on cell growth and invasion in PDAC cells. As a result of proteomics, 24 proteins were identified as candidate proteins which expression was regulated by lumican, and these candidate proteins included protein which is known apoptosis marker and protein which regulate MMP-9 activation. Thus, lumican might be involved in cell growth and invasion to regulate cell apoptosis and these proteins expression.
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| Free Research Field |
医歯薬科学
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