Study on the role of endoplasmic reticulum stress in the development of pancreatitis and new treatment through its amelioration

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591021
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kansai Medical University
• Principal Investigator: AKIYOSHI NISHIO 関西医科大学, 医学部, 准教授 (50362463)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 膵炎 / 小胞体ストレス / アポトーシス / セルレイン / エンドトキシン

Outline of Final Research Achievements

To clarify the role of endoplasmic reticulum stress in the development of acute pancreatitis, we created a murine model induced by administration of cerulein and lipopolysaccharide. GRP78 and CHOP proteins increased in the pancreas of mice with pancreatitis. In contrast, administration of an inhibitor of dephosphorylation of eIF2α suppressed pancreatitis, coupled with the increase in phosphorylated eIF2α and ATF4 and the decrease in GRP78 and CHOP protein. Suppression of protein synthesis and increase in ER stress-induced proteins by administration of the inhibitor are supposed to be involved in amelioration of pancreatitis, suggesting the usefulness of augmentation of PERK signaling pathway for the treatment of acute pancreatitis.

Free Research Field

消化器内科学、特に自己免疫消化器疾患