Identification of endocrine and exocrine stem/protenitor cells in the pancreas.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591023
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Keio University
• Principal Investigator: KO Shigeru 慶應義塾大学, 医学部, 講師 (90402578)
• Co-Investigator(Kenkyū-buntansha): KO Minoru 慶應義塾大学, 医学部, 教授 (50631199) ; NAKATAKE Yuhki 慶應義塾大学, 医学部, 助教 (20415251) ; ISHIGURO Hiroshi 名古屋大学, 総合保健体育科学センター, 教授 (90303651) ; YAMAMOTO Akiko 名古屋大学, 総合保健体育科学センター, 准教授 (60402385) ; NIIDA Shunpei 独立行政法人国立長寿医療研究センター, バイオバンク, バイオバンク長 (10137630) ; MATSUURA Toshihiro 独立行政法人国立長寿医療研究センター, 消化機能診療部, 部長 (80501626)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 膵組織再生 / 組織幹細胞

Outline of Final Research Achievements

We have examined the expression and lozalization pattern of stem/progenitor cell marker, LGR5, in human and mouse pancreas. In the human and mouse pancreas, LGR5 is localized in a very limited subpopulation of cells in the pancreas together with other stem/progenitor cell marker such as BMI1. These stem/progenitor cell marker positive cells are also positive for exocrine cell marker amylase or endocrine cell marker insulin or glucagon. These finding suggest that in the human or mouse pancreas, there is no isolated stem/progenitor cells in the organ but the subpopulation of mature differentiated cells are the cells that are responsible for tissue repair/regeneration.

Free Research Field

生理学