2016 Fiscal Year Final Research Report
Investigation of endoscopic and molecular diagnosis of colorectal serrated polyps
| Project/Area Number |
24591029
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Showa University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
KOBA Ikuro
Ohata Ken
MATSUYAMA Kyoji
YAMOCHI Toshiko
FUTAMURA Satoshi
|
|---|
| Project Period (FY) |
2012-04-01 – 2017-03-31
|
| Keywords | 大腸鋸歯状腺腫 / 内視鏡診断 / 大腸癌 / 大腸発癌 / 大腸内視鏡検査 |
|---|
| Outline of Final Research Achievements |
We performed the prospective study of differential endoscopic features of sessile serrated adenomas in the colorectum and concluded that the presence of mucus on the lesions may be a practicable finding for the differential diagnosis of sessile serrated adenoma/polyps (SSA/Ps) and hyperplastic polyps. Our molecular analysis suggested that distinct molecular features were observed between proximal and distal serrated polyps with hyperplastic crypt pattern and that ｐroximal microvesicular hyperplastic polyps (MVHPs) may develop more frequently through SSA/Ps to CpG island methylator phenotype (CIMP) cancers than dist al MVHPs. We performed methylated CpG island amplification microarrays in three paired proximal MVHPs and SSA/Ps with/without cytological dysplasia and found new candidate genes associated with the serrated pathway.
|
| Free Research Field |
大腸癌
|
