2014 Fiscal Year Final Research Report
ovel strategy for catheter interventional treatment of chronic thromboembolic pulmonary hypertension guided by optical coherence tomography imaging
| Project/Area Number |
24591032
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUKUMOTO Yoshihiro 久留米大学, 医学部, 教授 (70363372)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 経皮的肺動脈形成術 / 慢性血栓塞栓性肺高血圧症 / 光干渉断層法 |
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| Outline of Final Research Achievements |
Inoperable chronic thromboembolic pulmonary hypertension (CTEPH) still remains a fatal disease due to the lack of effective treatments. Optical coherence tomography (OCT) is an interferometer-based imaging modality.In our aim, in order to develop an effective and safe interventional treatment for CTEPH, we examined the effectiveness of our modified methods of OCT-guided percutaneous transluminal pulmonary angioplasty (PTPA). OCT examinations clearly showed the images of typical organic thrombus. We reported the effectiveness of PTPA in ERS international congress 2013in Barcelona. We examined thrombin-activated fibrinolysis inhibitor (TAFI) in blood sample from patients with CTEPH, and our results indicate that TAFI may be involved in the pathogenesis of CTEPH. We reported our results in AHA scientific sessions 2013.
Conclusion: OCT-guided PTPA markedly ameliorates pulmonary hemodynamics and RV functions in patients with inoperable CTEPH
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| Free Research Field |
循環器内科
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