2014 Fiscal Year Final Research Report
Effect of PPAR-gamma activation and AT-II receptor blockade on electrical and structural substrate of atrial fibrillation.
| Project/Area Number |
24591039
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | University of Toyama |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
INOUE Hiroshi 富山大学, 事務局, 理事・副学長 (60151619)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 心房細動 / リモデリング |
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| Outline of Final Research Achievements |
Irbesartan possesses angiotensin receptor blocking and peroxisome proliferator activated receptor gamma activating properties, and has demonstrated protective effect against atrial fibrillation (AF) in various situations. The effects of irbesartan were determined in a canine atrial tachypacing model. Beagles were subjected to atrial tachypacing for 4 weeks and either placebo (control dogs) or irbesartan (irbesartan dogs) was given through the study period. After 4 weeks of tachypacing, left ventricular diastolic dimension increased and left ventricular ejection fraction decreased for similar extent in both groups. AF duration increased in control dogs, but this change was suppressed in irbesartan dogs. AF inducibility also had a tendency to be suppressed in irbesartan dogs. Atrial effective refractory period was similarly shortened in both groups. Irbesartan suppressed AF development despite similar extent of left ventricular dysfunction in a canine atrial tachypacing model.
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| Free Research Field |
心房細動
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