Efficacy and Safety of Traditional Japanese Medicine (Kampo) for Chronic Heart Failure Patients with Cardiorenal Syndrome

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591042
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Shinshu University
• Principal Investigator: IZAWA Atsushi 信州大学, 学術研究院医学系(医学部附属病院), 講師 (50464095)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 慢性心不全 / 慢性腎臓病 / 心腎関連 / 東洋医学

Outline of Final Research Achievements

We aimed to explore efficacy and safety of Boiogito treatment, in combination with conventional medical therapy for chronic heart failure patients with cardiorenal syndrome (CRS). Boiogito was increased up to 7.5 g/day, and patients were evaluated at 3.5 and 9.4 months. Boiogito treatment significantly increased mean estimated glomerular filtration rate and decreased mean levels of blood urea nitrogen, serum creatinine and brain natriuretic peptide. Efficacy and safety of Boiogito treatment for both renal function and heart failure status were demonstrated in patients with CRS.

Free Research Field

医歯薬学