Development of new therapeutic strategies for dilated cardiomyopathy, ischemic cardiomyopathy with regenerative medicine

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591048
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Kyoto University
• Principal Investigator: NISHIO Ryosuke 京都大学, 医学(系)研究科(研究院), 助教 (00335275)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 心不全 / 心筋症 / 心筋梗塞 / リンパ管 / 心機能 / 免疫 / マイクロマシン

Outline of Final Research Achievements

We examined the therapeutic effects of VEGF-C156S, a lymphangiogenesis inducer, and VEGFR3-Fc, a lymphangiogenesis blocker in murine models of dilated cardiomyopathy and myocardial infarction. And we also established lymphangiogenesis factor treatments in the heart, and developed these treatments for clinical application in these murine models. In addition, we developed micro devices for clinical treatments in animal models. We have developed a method for controlling an array of cardiomyocytes. By using this technique, we examined the therapeutic effects of VEGF-C156S, a lymphangiogenesis inducer, and VEGFR3-Fc, a lymphangiogenesis blocker for application to clinical treatment strategies.

Free Research Field

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