Impact of Carnitine on Heart Failure with Preserved Ejection Fraction

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591049
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Osaka University
• Principal Investigator: SAKATA Yasushi 大阪大学, 医学(系)研究科(研究院), 教授 (00397671)
• Co-Investigator(Kenkyū-buntansha): OHTANI Tomohito 大阪大学, 大学院医学系研究科, 助教 (30623897) ; MANO Toshiaki 兵庫医科大学, 医学部, 准教授 (90379165)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: カルニチン / 心不全

Outline of Final Research Achievements

The expression of organic cation/carnitine transporter 2 (OCTN2) which uptakes carnitine with sodium in kidney was decreased at early hypertrophic stage in Dahl salt-sensitive rats that present hypertension and heart failure with preserved ejection fraction (HFpEF) with high salt diet. Urinary free-carnitine excretion also increased, and serum and cardiac level of carnitine decreased. Administration of L-carnitine with high salt diet from age 6 weeks attenuated the elevation of blood pressure and restored the expression of OCTN2 in kidney. Serum creatinine level was also attenuated with L-carnitine administration independently with systolic blood pressure. These data suggest that administration of carnitine may be effective to prevent the development of salt-sensitive hypertension, the worsening renal dysfunction and the transition to decompensated HFpEF.

Free Research Field

心不全