New risk stratification for cardiac sudden death by using signal averaged fragmented QRS complex

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591051
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Okayama University
• Principal Investigator: MORITA Hiroshi 岡山大学, 医歯(薬)学総合研究科, 教授 (50322227)
• Co-Investigator(Kenkyū-buntansha): TOH Norihisa 岡山大学, 大学病院, 助教 (70600641)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 心臓突然死 / fragmented QRS / 伝導障害 / 不整脈基質 / 12誘導心電図

Outline of Final Research Achievements

We created a software to analyze signal averaged fragmented QRS (fQRS) and evaluated its significances on various heart diseases. In 321 patients with Brugada syndrome, existence of fQRS, early repolarization and spontaneous fluctuation of the ST level were predictors of the ventricular fibrillation (VF) occurrence. In patients with new onset VF, aggravation of the fQRS occurred and progression of the myocardial injury should be required for occurrence of VF.
In 78 patients with non-ischemic dilated cardiomyopathy, existence of fQRS predicted occurrence of heart failure. In p127 patients with sarcoidosis, fQRS predicted occurrence of ventricular tachycardaia.

Free Research Field

循環器内科学