2014 Fiscal Year Final Research Report
Identification and Effects of KCNH2 (HERG) current-activating factor
| Project/Area Number |
24591054
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MORITA Hiroshi 岡山大学, 医歯薬学総合研究科, 教授 (50322227)
YOSHIDA Masashi 岡山大学, 医歯薬学総合研究科, 助教 (70532761)
ITO Hiroshi 岡山大学, 医歯薬学総合研究科, 教授 (90446047)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 心室性不整脈 / HERG電流 / 心不全 / イオンチャネル / QT延長症候群 / HEK293細胞 / 自己免疫 |
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| Outline of Final Research Achievements |
In order to improve the prognosis in patients with heart failure, to solve the mechanism of ventricular tachyarrhythmia and to find new target of treatment for ventricular tachyarrhythmia are needed. KCNH2 (HERG) channel is related to congenital long or short QT syndrome and is one of the most susceptible channel. We found ciruculating KCNH2(HERG) current-activating factor in patients with heart failure and ventricular tachyarrhythmia. We also found anti-KCNH2 antibody.
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| Free Research Field |
循環器内科学
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