メタボリック症候群を基盤とする非虚血性慢性心不全の病態解明と疾患概念の確立

2013 Fiscal Year Research-status Report

• Project/Area Number: 24591055
• Research Institution: Hiroshima University
• Principal Investigator: 木原 康樹 広島大学, 医歯薬保健学研究院(医), 教授 (40214853)
• Keywords: メタボリック症候群 / 心筋障害 / 心不全 / ミトコンドリア

Research Abstract

メタボリック症候群(内蔵肥満)に合併したうっ血性心不全患者の入院が増加しており、65歳以下の男性では心不全入院全体の7割近くを占めている。それら患者の2/3は虚血性心不全であるが残りの1/3は非虚血性であり、後者における心筋障害の原因は不明である。本研究はメタボリック症候群に合併する非虚血性心不全の本態が、「脂質過剰に起因する心筋ミトコンドリア代謝異常である」との仮説をSPECTやMRSを用いて臨床的に検討するとともに、経カテーテル的に得た心筋生検標本における遺伝子発現と免疫組織学的検索により直接の証明を試み、新たな疾患概念として「メタボリック心筋症」を検証する。65歳以下の男性でうっ血性心不全のため初回入院した患者を対象とする。冠動脈造影検査にて冠動脈疾患が否定された者をメタボリック症候群(日本動脈硬化学会等による診断基準2005年に拠る)の有無により、メタボリック群と非メタボリック群に分類する。臨床検査として123I-MIBG心筋SPECTによる脂肪酸代謝、MR Spectroscopyによる心筋脂肪酸代謝、心臓エコー検査による左室形態の定量的評価、心臓カテーテル検査による血行動態評価と心内膜下心筋生検を施行する。次いで心筋生検標本を用いた組織学的・分子生物学的検討を行い、ミトコンドリアのマスタースイッチであるERR-α/PCG-1シグナルを受けてMitDNA転写を直接制御していることを示し、Endonucrease Gの異常活性化仮説を証明する。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

対象患者をリクルートするため広島市内7基幹病院(広島市立安佐市民病院　土手慶五循環器内科主任部長、広島市立広島市民病院　井上一郎循環器内科主任部長、広島赤十字・原爆病院　岡田武規循環器内科部長、あかね会土谷総合病院　塩出宣雄循環器内科部長、JA広島総合病院　藤井隆循環器内科部長、県立広島病院　上田浩徳循環器内科部長、広島鉄道病院　寺川宏樹循環器内科部長)が研究協力者として参画している。研究に同意の得られた患者は広島大学病院循環器内科に転院し、インフォームドコンセントと文書による同意を確認後検討を行う。各群20名を目標としているが、現在10名のレジストレーションを終了することができた。

Strategy for Future Research Activity

対象症例20例の目標を達成し、その臨床評価・循環器的検索パラメターを明確にする。対象から得た心筋生検標本を用いて、免疫染色、電子顕微鏡的形態把握、PCRによる遺伝子発現状態の定量化を勧める。

Expenditure Plans for the Next FY Research Funding

予定した対象数に達しなかったために、それに費やす金額の執行が遅れた。
対象数を目標20例まで増加させることに集中し、予定の執行額を使用する。併せて分子生物学的評価の解析を実施する。

Research Products

• [Journal Article] Rho-associated kinase activity is a predictor of cardiovascular outcomes. (2014)
  • Author(s): Kajikawa M, Noma K, Maruhashi T, Mikami S, Iwamoto Y, Iwamoto A, Matsumoto T, Hidaka T, Kihara Y, Chayama K, Nakashima A, Goto C, Liao JK, Higashi Y.
  • Journal Title: Hypertension. Volume: 63(4) Pages: 856-64
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• [Journal Article] Role of DNA damage in cardiovascular disease. (2014)
  • Author(s): Ishida T, Ishida M, Tashiro S, Yoshizumi M, Kihara Y.
  • Journal Title: Circ J. Volume: 78(1) Pages: 42-50
• [Journal Article] Conversion from persistent to paroxysmal atrial fibrillation after pulmonary vein isolation is a good sign. (2014)
  • Author(s): Sairaku A, Yoshida Y, Hirayama H, Kihara Y.
  • Journal Title: Int J Cardiol. Volume: in press Pages: in press
  • DOI: PubMed PMID: 24680248.
  • Peer Reviewed
• [Journal Article] Clinical outcomes and causes of death in Japanese patients with long-term inferior vena cava filter implants and deep vein thrombosis. (2014)
  • Author(s): Iwamoto Y, Okamoto M, Hashimoto M, Fukuda Y, Uchimura Y, Iwamoto A, Matsumoto T, Iwasaki T, Kinoshita H, Ueda H, Kihara Y.
  • Journal Title: J Cardiol. Volume: in press Pages: in press
  • DOI: PubMed PMID: 24679943.
  • Peer Reviewed
• [Journal Article] Rationale and design of the PREDICT (Plaque Registration and Evaluation Detected In Computed Tomography) registry. (2014)
  • Author(s): Yamamoto H, Awai K, Kuribayashi S, Kihara Y; PREDICT Investigators.
  • Journal Title: J Cardiovasc Comput Tomogr. Volume: 8 Pages: 90-6
  • DOI: PubMed PMID: 24661823.
  • Peer Reviewed
• [Journal Article] Role of electrocardiography in the diagnosis and management of takotsubo cardiomyopathy. (2014)
  • Author(s): Kurisu S, Kihara Y.
  • Journal Title: Circ J. Volume: 78 Pages: 835-6
  • DOI: PubMed PMID: 24553193.
  • Peer Reviewed
• [Journal Article] Prognostic value of coronary artery calcium and epicardial adipose tissue assessed by non-contrast cardiac computed tomography. (2014)
  • Author(s): Kunita E, Yamamoto H, Kitagawa T, Ohashi N, Oka T, Utsunomiya H, Urabe Y, Tsushima H, Awai K, Budoff MJ, Kihara Y.
  • Journal Title: Atherosclerosis. Volume: 233 Pages: 447-53
  • DOI: PubMed PMID: 24530777.
  • Peer Reviewed
• [Journal Article] Poor oral health, that is, decreased frequency of tooth brushing, is associated with endothelial dysfunction. (2014)
  • Author(s): Kajikawa M, Nakashima A, Maruhashi T, Iwamoto Y, Iwamoto A, Matsumoto T, Hidaka T, Kihara Y, Chayama K, Goto C, Taguchi A, Noma K, Higashi Y.
  • Journal Title: Circ J. Volume: 78 Pages: 950-4
  • DOI: PubMed PMID: 24500034.
  • Peer Reviewed
• [Journal Article] Deterioration of the circadian variation of heart rate variability in Brugada syndrome may contribute to the pathogenesis of ventricular fibrillation. (2014)
  • Author(s): Tokuyama T, Nakano Y, Awazu A, Uchimura-Makita Y, Fujiwra M, Watanabe Y, Sairaku A, Kajihara K, Motoda C, Oda N, Kihara Y.
  • Journal Title: J Cardiol. Volume: in press Pages: in press
  • DOI: PubMed PMID: 24495503.
  • Peer Reviewed
• [Journal Article] Effects of eplerenone on P-wave signal-averaged electrocardiogram in hypertensive patients with coronary artery disease. (2014)
  • Author(s): Kurisu S, Watanabe N, Ikenaga H, Shimonaga T, Higaki T, Iwasaki T, Mitsuba N, Ishibashi K, Dohi Y, Kihara Y.
  • Journal Title: Int J Cardiol. Volume: 172 Pages: 180-1
  • DOI: PubMed PMID: 24439863.
  • Peer Reviewed
• [Journal Article] Increased mean platelet volume in patients with coronary artery disease and its seasonal variation. (2014)
  • Author(s): Kurisu S, Watanabe N, Ikenaga H, Shimonaga T, Higaki T, Iwasaki T, Mitsuba N, Ishibashi K, Dohi Y, Kihara Y.
  • Journal Title: Int J Cardiol. Volume: 172 Pages: 159-61
  • DOI: PubMed PMID: 24405836.
  • Peer Reviewed
• [Journal Article] Influence of left ventricular geometry on thallium-201 gated single-photon emission tomographic findings in patients with known or suspected coronary artery disease. (2014)
  • Author(s): Kurisu S, Iwasaki T, Ikenaga H, Watanabe N, Higaki T, Shimonaga T, Ishibashi K, Mitsuba N, Dohi Y, Kihara Y.
  • Journal Title: Ann Nucl Med. Volume: 28 Pages: 120-7
  • DOI: PubMed PMID: 24254429.
  • Peer Reviewed
• [Journal Article] Periprocedural coagulability in patients undergoing ablation of atrial fibrillation: lessons from a periablation anticoagulation strategy of a brief withdrawal of warfarin without heparin bridging. (2014)
  • Author(s): Sairaku A, Yoshida Y, Hirayama H, Nakano Y, Kihara Y.
  • Journal Title: J Thromb Thrombolysis. Volume: in press Pages: in press
  • DOI: PubMed PMID: 23943339.
  • Peer Reviewed
• [Journal Article] Positive action is required to achieve the 2020.30 goal of gender equality in Japanese medical societies. (2014)
  • Author(s): Hiyama K, Ozaki M, Hayano K, Yamamoto N, Bando H, Maeda K, Kihara Y, Murashima A.
  • Journal Title: Surg Today. Volume: 44 Pages: 204-5
  • DOI: PubMed PMID: 23636295.
  • Peer Reviewed
• [Journal Article] Positive influence of aspirin on coronary endothelial function: Importance of the dose. (2013)
  • Author(s): Teragawa H, Mitsuba N, Ishibashi K, Kurisu S, Kihara Y.
  • Journal Title: World J Cardiol. Volume: 5 Pages: 426-33
  • DOI: PubMed PMID:24340141.
  • Peer Reviewed
• [Journal Article] Don't move during ablation of atrial fibrillation! (2013)
  • Author(s): Sairaku A, Yoshida Y, Hirayama H, Nakano Y, Kondo N, Kihara Y.
  • Journal Title: Int J Cardiol. Volume: 171 Pages: 78-81
  • DOI: PubMed PMID: 24315338.
  • Peer Reviewed
• [Journal Article] Prediction of atrial fibrillation after off-pump coronary artery bypass grafting using preoperative total atrial conduction time determined on tissue Doppler imaging. (2013)
  • Author(s): Fujiwara M, Nakano Y, Hidaka T, Oda N, Uchimura Y, Sairaku A, Kajihara K, Tokuyama T, Motoda C, Watanabe Y, Ikenaga H, Imai K, Sueda T, Kihara Y.
  • Journal Title: Circ J. Volume: 78 Pages: 345-52
  • DOI: PubMed PMID: 24284884.
  • Peer Reviewed
• [Journal Article] Hyperuricemia is independently associated with endothelial dysfunction in postmenopausal women but not in premenopausal women. (2013)
  • Author(s): Maruhashi T, Nakashima A, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, Kajikawa M, Matsumoto T, Hidaka T, Kihara Y, Chayama K, Goto C, Noma K, Tomiyama H, Takase B, Yamashina A, Higashi Y.
  • Journal Title: BMJ Open. Volume: 3 Pages: 3659
  • DOI: PubMed PMID: 24213096.
  • Peer Reviewed
• [Journal Article] Relationship between flow-mediated vasodilation and cardiovascular risk factors in a large community-based study. (2013)
  • Author(s): Maruhashi T, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, Kajikawa M, Matsumoto T, Hidaka T, Kihara Y, Chayama K, Noma K, Nakashima A, Goto C, Tomiyama H, Takase B, Yamashina A, Higashi Y.
  • Journal Title: Heart. Volume: 99 Pages: 1837-42
  • DOI: PubMed PMID: 24153417.
  • Peer Reviewed
• [Journal Article] Dose napkin-ring sign suggest possibility to identify rupture-prone plaque in coronary computed tomography angiography? (2013)
  • Author(s): Yamamoto H, Kitagawa T, Kihara Y.
  • Journal Title: J Cardiol. Volume: 62 Pages: 328-9
  • DOI: PubMed PMID: 24139820.
  • Peer Reviewed
• [Journal Article] A head-to-head comparison of periprocedural coagulability under anticoagulation with rivaroxaban versus dabigatran in patients undergoing ablation of atrial fibrillation. (2013)
  • Author(s): Sairaku A, Yoshida Y, Ando M, Hirayama H, Nakano Y, Kihara Y.
  • Journal Title: Clin Drug Investig. Volume: 33 Pages: 847-53
  • DOI: PubMed PMID: 24081373.
  • Peer Reviewed
• [Journal Article] Percutaneous coronary intervention for postcardiac arrest syndrome. (2013)
  • Author(s): Kagawa E, Dote K, Kihara Y.
  • Journal Title: Curr Opin Cardiol. Volume: 28 Pages: 689-94
  • DOI: PubMed PMID: 24077609.
  • Peer Reviewed
• [Journal Article] Conditions associated with increased mean platelet volume. (2013)
  • Author(s): Kurisu S, Kihara Y.
  • Journal Title: Int J Cardiol. Volume: 169 Pages: 90
  • DOI: PubMed PMID: 23992934.
  • Peer Reviewed
• [Journal Article] Ablation of atrial fibrillation in Brugada syndrome patients with an implantable cardioverter defibrillator to prevent inappropriate shocks resulting from rapid atrial fibrillation. (2013)
  • Author(s): Sairaku A, Yoshida Y, Nakano Y, Kihara Y.
  • Journal Title: Int J Cardiol. Volume: 168 Pages: 5273-6
  • DOI: PubMed PMID: 23988302.
  • Peer Reviewed
• [Journal Article] Incremental prognostic value of cardiac computed tomography angiography in asymptomatic aortic stenosis: significance of aortic valve calcium score. (2013)
  • Author(s): Utsunomiya H, Yamamoto H, Kitagawa T, Kunita E, Urabe Y, Tsushima H, Hidaka T, Awai K, Kihara Y.
  • Journal Title: Int J Cardiol. Volume: 168 Pages: 5205-11
  • DOI: PubMed PMID: 23978365.
  • Peer Reviewed
• [Journal Article] Double-blind, placebo-controlled clinical trial with a rho-kinase inhibitor in pulmonary arterial hypertension. (2013)
  • Author(s): Fukumoto Y, Yamada N, Matsubara H, Mizoguchi M, Uchino K, Yao A, Kihara Y, Kawano M, Watanabe H, Takeda Y, Adachi T, Osanai S, Tanabe N, Inoue T, Kubo A, Ota Y, Fukuda K, Nakano T, Shimokawa H.
  • Journal Title: Circ J. Volume: 77 Pages: 2619-25
  • DOI: PubMed PMID: 23912836.
  • Peer Reviewed
• [Journal Article] A novel noninvasive and simple method for assessment of endothelial function: enclosed zone flow-mediated vasodilation (ezFMD) using an oscillation amplitude measurement. (2013)
  • Author(s): Idei N, Ukawa T, Kajikawa M, Iwamoto Y, Fujimura N, Maruhashi T, Mikami S, Matsumoto T, Kihara Y, Chayama K, Noma K, Nakashima A, Takayanagi T, Morimoto H, Tsuji T, Higashi Y.
  • Journal Title: Atherosclerosis. Volume: 229 Pages: 324-30
  • DOI: PubMed PMID: 23880183.
  • Peer Reviewed
• [Journal Article] Variable procedural strategies adapted to anatomical characteristics in catheter ablation of the cavotricuspid isthmus using a preoperative multidetector computed tomography analysis. (2013)
  • Author(s): Kajihara K, Nakano Y, Hirai Y, Ogi H, Oda N, Suenari K, Makita Y, Sairaku A, Tokuyama T, Motoda C, Fujiwara M, Watanabe Y, Kiguchi M, Kihara Y.
  • Journal Title: J Cardiovasc Electrophysiol. Volume: 24 Pages: 1344-51
  • DOI: PubMed PMID: 23875907.
  • Peer Reviewed
• [Journal Article] Association between serum levels of n-3 polyunsaturated fatty acids and coronary plaque detected by coronary computed tomography angiography in patients receiving statin therapy. (2013)
  • Author(s): Urabe Y, Yamamoto H, Kitagawa T, Utsunomiya H, Tsushima H, Tatsugami F, Awai K, Kihara Y.
  • Journal Title: Circ J. Volume: 77 Pages: 2578-85
  • DOI: PubMed PMID: 23863750.
  • Peer Reviewed
• [Journal Article] ST-segment elevation in V1-V3 in patients with inferior STEMI: an important sign of right ventricular infarction (reply). (2013)
  • Author(s): Kurisu S, Kihara Y.
  • Journal Title: Intern Med. Volume: 52 Pages: 1663
  • DOI: PubMed PMID: 23857109.
  • Peer Reviewed
• [Journal Article] Noncalcified atherosclerotic lesions with vulnerable characteristics detected by coronary CT angiography and future coronary events. (2013)
  • Author(s): Yamamoto H, Kitagawa T, Ohashi N, Utsunomiya H, Kunita E, Oka T, Urabe Y, Tsushima H, Awai K, Kihara Y.
  • Journal Title: J Cardiovasc Comput Tomogr. Volume: 7 Pages: 192-9
  • DOI: PubMed PMID: 23849492.
  • Peer Reviewed
• [Journal Article] Clinical significance of sleep-disordered breathing induced by sedatives during ablation of atrial fibrillation. (2013)
  • Author(s): Sairaku A, Yoshida Y, Hirayama H, Nakano Y, Nanasato M, Kamiya H, Kondo N, Kihara Y.
  • Journal Title: Sleep Med. Volume: 14 Pages: 622-7
  • DOI: PubMed PMID:23719478.
  • Peer Reviewed
• [Journal Article] Longitudinal extent of lipid pool assessed by optical coherence tomography predicts microvascular no-reflow after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. (2013)
  • Author(s): Ikenaga H, Ishihara M, Inoue I, Kawagoe T, Shimatani Y, Miura F, Nakama Y, Dai K, Ohtani T, Ohi K, Miki T, Nakamura M, Kishimoto S, Sumimoto Y, Kihara Y.
  • Journal Title: J Cardiol. Volume: 62 Pages: 71-6
  • DOI: PubMed PMID: 23680004.
  • Peer Reviewed
• [Journal Article] Mean platelet volume in patients with primary aldosteronism and its relation to left ventricular hypertrophy. (2013)
  • Author(s): Kurisu S, Shimonaga T, Iwasaki T, Mitsuba N, Ishibashi K, Dohi Y, Kihara Y.
  • Journal Title: Int J Cardiol. Volume: 168 Pages: 3143-4
  • DOI: PubMed PMID: 23664052.
  • Peer Reviewed
• [Journal Article] Nitroglycerine-induced vasodilation for assessment of vascular function: a comparison with flow-mediated vasodilation. (2013)
  • Author(s): Maruhashi T, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, Kajikawa M, Matsumoto T, Hidaka T, Kihara Y, Chayama K, Noma K, Nakashima A, Goto C, Higashi Y.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 33 Pages: 1401-8
  • DOI: PubMed PMID:23520168.
  • Peer Reviewed
• [Journal Article] Appearance of neointima according to stent type and restenotic phase: analysis by optical coherence tomography. (2013)
  • Author(s): Goto K, Takebayashi H, Kihara Y, Hagikura A, Fujiwara Y, Kikuta Y, Sato K, Kodama S, Taniguchi M, Hiramatsu S, Haruta S.
  • Journal Title: EuroIntervention. Volume: 9 Pages: 601-7
  • DOI: PubMed PMID:23518860.
  • Peer Reviewed
• [Journal Article] Comparison of treatment and outcome of acute myocardial infarction between cancer patients and non-cancer patients. (2013)
  • Author(s): Kurisu S, Iwasaki T, Ishibashi K, Mitsuba N, Dohi Y, Kihara Y.
  • Journal Title: Int J Cardiol. Volume: 167 Pages: 2335-7
  • DOI: PubMed PMID: 23201078.
  • Peer Reviewed
• [Journal Article] Effect of body mass index on the location of the right adrenal vein in patients with primary aldosteronism. (2013)
  • Author(s): Iwasaki T, Kurisu S, Mitsuba N, Ishibashi K, Dohi Y, Nishioka K, Kihara Y.
  • Journal Title: J Renin Angiotensin Aldosterone Syst. Volume: 14 Pages: 156-60
  • DOI: PubMed PMID:22842543.
  • Peer Reviewed
• [Journal Article] Left atrial thickness under the catheter ablation lines in patients with paroxysmal atrial fibrillation: insights from 64-slice multidetector computed tomography. (2013)
  • Author(s): Suenari K, Nakano Y, Hirai Y, Ogi H, Oda N, Makita Y, Ueda S, Kajihara K, Tokuyama T, Motoda C, Fujiwara M, Chayama K, Kihara Y.
  • Journal Title: Heart Vessels. Volume: 28 Pages: 360-8
  • DOI: PubMed PMID: 22526381.
  • Peer Reviewed
• [Presentation] 18F-FPPRGD2 Positron Emission Tomography for Detecting Active Changes in Biological Function of Abdominal Aortic Aneurysms (2014)
  • Author(s): T,Kitagawa, H.Kosuge, Y.Kihara
  • Organizer: The 78th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 東京
  • Year and Date: 20140321-20140323
• [Presentation] The Electrophysiological Properties in Patients with Tachycardia-induced Cardiomyopathy Resulting from Rapid Atrial Fibrillation (2014)
  • Author(s): A.Sairaku, Y.Nakano, Y.Uchimura, T.Tokuyama, H.Kawazoe, M.Fujiwara, Y.Watanabe, H.Matsumura, N.Oda, Y.Kihara
  • Organizer: The 78th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 東京
  • Year and Date: 20140321-20140323
• [Presentation] Age- and Sex-Related Differences in Coronary Plaque High-Risk Features in Patients with Acute Coronary Syndrome Assessed by Computed Tomography Angiography (2014)
  • Author(s): T.Kitagawa, H.Yamamoto, Y.Urabe ,H.Tsushima, Y.Kihara
  • Organizer: The 78th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 東京
  • Year and Date: 20140321-20140323
• [Presentation] The Left Atrial Pressure Overload Causes Atrial Conduction Disturbances (2014)
  • Author(s): A.Sairaku, Y.Nakano, Y.Uchimura, T.Tokuyama, H.Kawazoe ,M.Fujiwara, Y.Watanabe ,H.Matsumura, N.Oda, Y.Kihara
  • Organizer: The 78th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 東京
  • Year and Date: 20140321-20140323
• [Presentation] Nitroglycerine-induced Vasodilation in the Brachial Artery and Cardiovascular Risk Factors (2014)
  • Author(s): T.Maruhashi, Y.Higashi, Y.Iwamoto, T.Matsumoto , M.Kajikawa , A.Iwamoto, T.Hidaka, A.Nakashima, K.Noma, Y.Kihara
  • Organizer: The 78th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 東京
  • Year and Date: 20140321-20140323
• [Presentation] The Relationship between Strokes and CHA2DS2VASc in the Real World of Atrial Fibrillation Ablation (2014)
  • Author(s): Y.Watanabe, Y.Nakano, N.Oda, M.Matsumura, H.Kawazoe, M.Fujiwara, T.Tokuyama, Y.Uchimura, A.Sairaku, Y.Kihara
  • Organizer: The 78th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 東京
  • Year and Date: 20140321-20140323
• [Presentation] Mean Platelet Volume in Patients with Aortic Valve Stenosis and Its Relation to Left Ventricular Hypertrophy (2014)
  • Author(s): S.Kurisu, H.Ikenaga, N.Watanabe, T.Higaki, T.Shimonaga, T.Iwasaki, K.Ishibashi, N.Mitsuba, Y.Dohi, Y.Kihara
  • Organizer: The 78th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 東京
  • Year and Date: 20140321-20140323
• [Presentation] Survey on Hospitalization and Costs of Provisional Heart-Failure Patients Based on Elevated Levels of BNP in Entire Hiroshima-Prefecture District (2014)
  • Author(s): Y.Kihara
  • Organizer: The 78th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 東京
  • Year and Date: 20140321-20140323
  • Invited
• [Presentation] Rho-Associated Kinase Activity and Risk of Cardiovascular Events (2014)
  • Author(s): M.Kajikawa, Y.Higashi, A.Iwamoto, T.Matsumoto , Y.Iwamoto, T.Maruhashi, K.Noma, A.Nakashima , L.James K, Y.Kihara
  • Organizer: The 78th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 東京
  • Year and Date: 20140321-20140323
• [Presentation] Difference between Nitroglycerine-induced Vasodilation and Flow-mediated Vasodilation in Association with the Severity of Atherosclerosis (2014)
  • Author(s): T.Maruhashi, Y.Higashi, Y.Iwamoto, T.Matumoto, M.Kajikawa, A.Iwamoto, T.Hidaka, A.Nakashima, K.Noma, Y.Kihara
  • Organizer: The 78th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 東京
  • Year and Date: 20140321-20140323
• [Presentation] Initial Impact of Epicardial Adipose Tissue on Non-calcified Plaques in Patients with Low-risk Coronary Atherosclerosis (2014)
  • Author(s): H.Tsushima, H.Yamamoto, T.Kitagawa, H.Utsunomiya, Y.Urabe, Y.Kihara
  • Organizer: The 78th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 東京
  • Year and Date: 20140321-20140323
• [Presentation] Nonsynonymous Polymorphism in Semaphorin 3A is a New Genetic Risk Factor for Human Idiopathic Ventricular Fibrillation (2014)
  • Author(s): Y.Nakano, M.Toshisige, H.Ochi, T.Tokuyama, A.Sairaku, N.Oda, K.Kajiahara, Y.Uchimura, M.Fujiwara, Y.Watanabe, H.Kawazoe, C.Motoda, M.Matumura, N.Oda, T.Aiba, H.Watanabe, W.Schimizu, M.Horie, N.Makita, K.Chayama, Y.Kihara
  • Organizer: The 78th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 東京
  • Year and Date: 20140321-20140323
• [Presentation] Poor Oral Health Behavior is Associated with Endothelial Dysfunction (2014)
  • Author(s): M.Kajikawa, Y.Higashi, A.Nakashima, Y.Iwamoto, T.Matsumoto, A.Iwamoto, T.Maruhashi, T.Hidaka, K.Noma, A.Taguchi, Y.Kihara
  • Organizer: The 78th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 東京
  • Year and Date: 20140321-20140323
• [Presentation] ROCK as a Modulator of Sustained Vasoconstriction of Resistance Artery in Patients with Essential Hypertension (2014)
  • Author(s): K.Noma, Y.Higashi, C.Goto, Y.Kihara, James Liao
  • Organizer: The 78th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 東京
  • Year and Date: 20140321-20140323
• [Presentation] Corkscrew Collateral Artery in Raynaud´s Syndrome (2014)
  • Author(s): Y.Fujii, H.Teragawa, T.Ueda, S.Nomura, Y.Kihara, Y.Higashi
  • Organizer: The 78th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 東京
  • Year and Date: 20140321-20140323
• [Presentation] Durations and Temperature Management for Comatose Survivors of Cardiac Arrest Treated with or without Percutaneous Coronary Intervention (2014)
  • Author(s): E.Kagawa, K.Dote, M.Kato, S.Sasaki, N.Oda, Y.Nakano, Y.Sumimoto, H.Honda, Y.Takaeko, I.Inoue, T.Kawagoe, M.Ishihara, Y.Kihara
  • Organizer: The 78th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 東京
  • Year and Date: 20140321-20140323
• [Presentation] Smoking and DNA Damage (2014)
  • Author(s): M.Ishida, T.Ishida, Y.Kihara, M.Yoshizumi
  • Organizer: The 78th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 東京
  • Year and Date: 20140321-20140323
• [Presentation] Identifying Small Coronary Calcification in Non-contrast 0.5mm-slice-reconstruction to Diagnose Coronary Artery Disease in Patients with Conventional Zero Coronary Calcium Scores (2014)
  • Author(s): Y.Urabe, H.Yamamoto, T.Kitagawa, H.Utsunomiya, H.Tsushima, Y.Kihara
  • Organizer: The 78th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 東京
  • Year and Date: 20140321-20140323
• [Presentation] Differentiations of Transition of the Thoracic Impedance According to Excessive Fluid Volume of Patient with Decompensated Heart Failure (2014)
  • Author(s): N.Oda, Y.Nakano, Y.Takaeko, H.Honda, K.Miura, A.Yamane, Y.Sumimoto, Y.Nakano, E.Kagawa, S.Sasaki, M.Kato, K.Nishioka, H.Ueda, N.Shiode, H.Teragawa, K.Dote, Y.Kihara
  • Organizer: The 78th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 東京
  • Year and Date: 20140321-20140323
• [Presentation] Left Atrial Mechanical and Substrate Abnormality Assessed by Three-dimensional Echocardiography and Electroanatomical Mapping System in Patients with Paroxysmal Atrial Fibrillation (2014)
  • Author(s): Y.Watanabe, Y.Nakano, N.Oda, M.Matsumura, H.Kawazoe ,M.Fujiwara, A.Motoda, T.Tokuyama, A.Sairaku, Y.Uchimura, T.Hidaka ,Y.Kihara
  • Organizer: The 78th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 東京
  • Year and Date: 20140321-20140323
• [Presentation] Abnormal Airway Resistance and Reactance Limit Exercise Capacity in Patients with Chronic Heart Failure (2013)
  • Author(s): T.Hidaka,H.Utsunomiya,N.Mitsuba,K.Ishibashi,T.Kitagawa,Y.Dohi,S.Kurisu,Y.Nakano,H.Yamamoto,Y.Kihara
  • Organizer: 第17回日本心不全学会学術集会
  • Place of Presentation: 埼玉
  • Year and Date: 20131128-20131130
• [Presentation] Survey on Hospitalization Frequency of Provisional Heart Failure Patients Based on Elevated Levels of BNP in the Whole Hiroshima Area (2013)
  • Author(s): T.Kitagawa,T.Kisaka,N.Oda,H.Kinoshita,T.Higaki,M.Mizukawa,M.Shimomura,Y.Kihara
  • Organizer: 第17回日本心不全学会学術集会
  • Place of Presentation: 埼玉
  • Year and Date: 20131128-20131130
• [Presentation] Independent Prognostic Value of Right Atrial Pressure in Patients with Congestive Heart Disease (2013)
  • Author(s): Y.Sada,H.Kinoshita,T.Kisaka,Y.Dohi,Y.Kihara
  • Organizer: 第17回日本心不全学会学術集会
  • Place of Presentation: 埼玉
  • Year and Date: 20131128-20131130
• [Presentation] Detection of Developing Pulmonary Vasculopathy in the Early Stage of Pulmonary Arterial Hypertension with Non-invasive Cardiopulmonary Exercise Testing (2013)
  • Author(s): H.Kinoshita,Y.Dohi,Y.Sada,T.Kisaka,T.Kitagawa,H.Yamamoto,Y.Kihara
  • Organizer: 第17回日本心不全学会学術集会
  • Place of Presentation: 埼玉
  • Year and Date: 20131128-20131130
• [Presentation] ３Ｄスキャナを用いた心不全症例の姿勢による体液移動の評価 (2013)
  • Author(s): 田代尚範、牛尾会、日山景、砂川加奈子、日髙貴之、木村浩彰、木原康樹
  • Organizer: 第17回日本心不全学会学術集会
  • Place of Presentation: 埼玉
  • Year and Date: 20131128-20131130
• [Presentation] 慢性心不全患者に対する心不全センターにおける薬剤師の介入効果 (2013)
  • Author(s): 増田有紀、櫻下弘志、水川真理子、木原康樹、木平健治
  • Organizer: 第17回日本心不全学会学術集会
  • Place of Presentation: 埼玉
  • Year and Date: 20131128-20131130
• [Presentation] Is a Pressure Wire During the Spasm Provocation Useful for the Diagnosis of Vasospastic Angina? (2013)
  • Author(s): H.Teragawa,Y.Fujii,T.Ueda,S.Nomura,Y.Kihara
  • Organizer: Scientific Sessions 2013 American Heart Association
  • Place of Presentation: Dallas, Texas,USA
  • Year and Date: 20131116-20131120
• [Presentation] Nonsynonymous Polymorphism in Semaphorin 3A as a Risk Factor for Human Unexplained Cardiac Arrest With Documented Ventricular Fibrillation (2013)
  • Author(s): Y.Nakano,K.Chayama,H.Ochi,M.Toshishige,T.Tokuyama,N.Oda,Y.Uchimura(Makita),K.Kajihara,A.Sairaku,C.Motoda,M.Fujiwara,Y.Watanabe,H.Kawazoe,H.Ikenaga,S.Matsumoto,N.Oda,K.Suenari,Y.Yoshida,K.Ohkubo,I.Watanabe,A.Nogami,H.Watanabe,K.Hasegawa,T.Aiba,S.Ohno,W.Shimizu,M.Horie,S.Tashiro,N.Makita,Y.Kihara
  • Organizer: Scientific Sessions 2013 American Heart Association
  • Place of Presentation: Dallas, Texas,USA
  • Year and Date: 20131116-20131120
• [Presentation] Left Atrial Mechanical and Substrate Abnormalities Assessed by Three-Dimensional Speckle-Tracking Echocardiography and Electroanatomical Mapping System in Patients With Paroxysmal Atrial Fibrillation (2013)
  • Author(s): Y.Watanabe,Y.Nakano,M.Matsumoto,N.Oda,H.Kawazoe,M.Fujiwara,A.Motoda,T.Tokuyama,A.Sairaku,T.Hidaka,Y.Kihara
  • Organizer: Scientific Sessions 2013 American Heart Association
  • Place of Presentation: Dallas, Texas,USA
  • Year and Date: 20131116-20131120
• [Presentation] Peripheral Augmentation Index is an Index of not Only Arterial Stiffness but Also Endothelial Function (2013)
  • Author(s): T.Matsumoto,Y.Higashi,A.Iwamoto,M.Kajikawa,Y.Iwamoto,S.Mikami,T.Maruhashi,T.Hidaka,A.Nakashima,K.Noma,Y.Kihara
  • Organizer: Scientific Sessions 2013 American Heart Association
  • Place of Presentation: Dallas, Texas,USA
  • Year and Date: 20131116-20131120
• [Presentation] Procedural Sedation With Dexmedetomidine During Ablation of Atrial Fibrillation: A Randomized Controlled Trial (2013)
  • Author(s): A.Sairaku,Y.Yoshida,M.Ando,H.Hiroyama,Y.Nakano,Y.Kihara
  • Organizer: Scientific Sessions 2013 American Heart Association
  • Place of Presentation: Dallas, Texas,USA
  • Year and Date: 20131116-20131120
• [Presentation] Family History of Coronary Artery Disease - Does it Differ According to the Types of Coronary Artery Disease? (2013)
  • Author(s): H.Teragawa,Y.Fujii,T.Ueda,S.Nomura,Y.Kihara
  • Organizer: Scientific Sessions 2013 American Heart Association
  • Place of Presentation: Dallas, Texas,USA
  • Year and Date: 20131116-20131120
• [Presentation] Calcium Deposits in Heart Valves and Aortic Root, Cardiovascular Risk Factors, Subclinical Coronary Atherosclerosis, and the Risk of Future Cardiovascular Events (2013)
  • Author(s): H.Utsunomiya,H.Yamamoto,H.Tsushima,Y.Urabe,T.Maruhashi,K.Ishibashi,N.Mitsuba,T.Kitagawa,T.Hidaka,Y.Dohi,S.Kurisu,Y.Nakano,T.Ishida,Y.Kihara
  • Organizer: Scientific Sessions 2013 American Heart Association
  • Place of Presentation: Dallas, Texas,USA
  • Year and Date: 20131116-20131120
• [Presentation] Variable Procedural Strategies Adapted to Anatomical Characteristics in Catheter Ablation of the Cavotricuspid Isthmus Using a Preoperative Multidetector Computed Tomography Analysis (2013)
  • Author(s): K.Kajihara,Y.Nakano,Y.Makita,A.Sairaku,T.Tokuyama,C.Motoda,M.Fujiwara,Y.Watanabe,N.Oda,Y.Kihara
  • Organizer: Scientific Sessions 2013 American Heart Association
  • Place of Presentation: Dallas, Texas,USA
  • Year and Date: 20131116-20131120
• [Presentation] Time-Domain T-Wave Alternans in Lead V2 is Useful for Predicting Ventricular Arrhythmias in Patients With Brugada Syndrome (2013)
  • Author(s): Y.Uchimura(Makita),Y.Nakano,A.Sairaku,T.Tokuyama,M.Fujiwara,Y.Watanabe,H.Kawazoe,M.Matsumura.N.Oda,Y.Kihara
  • Organizer: Scientific Sessions 2013 American Heart Association
  • Place of Presentation: Dallas, Texas,USA
  • Year and Date: 20131116-20131120
• [Presentation] 心不全患者を幸せにする心臓超音波検査：チーム医療におけるエコー検査の位置づけと役割 (2013)
  • Author(s): 木原康樹
  • Organizer: 日本超音波医学会第40回関西地方会学術集会第１７回関西地方講習会
  • Place of Presentation: 大阪
  • Year and Date: 20131109-20131109
  • Invited
• [Presentation] 組織ドッブラー法を用いたoff-pump CABG(OPCAB)後の術後心房細動の発症予測 (2013)
  • Author(s): 藤原舞、中野由紀子、日髙貴之、内村祐子、西樂顕典、徳山丈仁、渡邉義和、川副宏、小田望、松村誠也、木原康樹
  • Organizer: 第103回日本循環器学会中国地方会
  • Place of Presentation: 鳥取
  • Year and Date: 20131026-20131026
• [Presentation] 食道癌放射線治療の遠隔期に冠動脈障害を来した一例 (2013)
  • Author(s): 山路貴之、石橋堅、檜垣忠直、宇都宮裕人、光波直也、北川知郎、日髙貴之、土肥由裕、栗栖智、中野由紀子、山本秀也、石田隆史、木原康樹
  • Organizer: 第103回日本循環器学会中国地方会
  • Place of Presentation: 鳥取
  • Year and Date: 20131026-20131026
• [Presentation] 周産期心筋症に対するブロモクリプチンの効果 (2013)
  • Author(s): 大谷俊人、土肥由裕、渡邊紀晶、西樂顕典、北川知郎、日髙貴之、栗栖智、中野由紀子、山本秀也、石田隆史、木原康樹
  • Organizer: 第103回日本循環器学会中国地方会
  • Place of Presentation: 鳥取
  • Year and Date: 20131026-20131026
• [Presentation] 農村における閉寒性動脈硬化症の発生率と下腿径について (2013)
  • Author(s): 三上慎祐、横矢仁、中井訓治、植田裕介、廣延直也、小林賢悟、友森俊介、田中幸一、東幸仁、木原康樹
  • Organizer: 第103回日本循環器学会中国地方会
  • Place of Presentation: 鳥取
  • Year and Date: 20131026-20131026
• [Presentation] 血圧重傷度と血管内皮機能の横断研究：FMD-Japan StudyFlow-mediated Vasodilation(FMD)and Blood Pressure:FMD-Japan Study. (2013)
  • Author(s): 梶川正人、東幸仁、岩本明倫、松本武史、岩本由美子、丸橋達也、中島歩、野間玄督、冨山博史、高瀬凡平、山科章、木原康樹
  • Organizer: 第36回日本高血圧学会総会
  • Place of Presentation: 大阪
  • Year and Date: 20131024-20131026
• [Presentation] 75歳以上の患者における末梢動脈病変の発症率と危険因子に関する検討 (2013)
  • Author(s): 三上慎祐、中井訓治、中西敏夫、横矢仁、東幸仁、木原康樹
  • Organizer: 第36回日本高血圧学会総会
  • Place of Presentation: 大阪
  • Year and Date: 20131024-20131026
• [Presentation] NOとROCK活性の関連：外的NOは血管平滑筋細胞のROCK活性を抑制する Association between NO and ROCK:Exogenous NO Inhibits ROCK Activity in Smooth Muscle Cells. (2013)
  • Author(s): 丸橋達也、東幸仁、岩本明倫、梶川正人、松本武史、岩本由美子、日髙貴之、中島歩、野間玄督、木原康樹
  • Organizer: 第36回日本高血圧学会総会
  • Place of Presentation: 大阪
  • Year and Date: 20131024-20131026
• [Presentation] 動脈硬化マーカーとしてのニトログリセリン誘発性血管拡張反応について Nitroglycerine-induced Vasodilation as a Marker of Atherosclerosis. (2013)
  • Author(s): 丸橋達也、東幸仁、岩本明倫、梶川正人、松本武史、岩本由美子、日髙貴之、中島歩、野間玄督、木原康樹
  • Organizer: 第36回日本高血圧学会総会
  • Place of Presentation: 大阪
  • Year and Date: 20131024-20131026
• [Presentation] 心肺運動負荷試験による肺動脈性肺高血圧患者検出についての研究 (2013)
  • Author(s): 木下弘喜、土肥由裕、佐田良治、木原康樹
  • Organizer: 第1回日本肺高血圧学会学術集会
  • Place of Presentation: 神奈川
  • Year and Date: 20131013-20131014
• [Presentation] 右房圧はうっ血性心不全の強力な予後予測因子である (2013)
  • Author(s): 佐田良治、木下弘喜、土肥由裕、木原康樹
  • Organizer: 第1回日本肺高血圧学会学術集会
  • Place of Presentation: 神奈川
  • Year and Date: 20131013-20131014
• [Presentation] 高血圧治療ガイドライン(JSH2014)改訂のポイントと高血圧治療の到達点 (2013)
  • Author(s): 木原康樹
  • Organizer: 広島県内科学会 学術講演会
  • Place of Presentation: 広島
  • Year and Date: 20130930-20130930
  • Invited
• [Presentation] 大動脈弁再建術後患者では運動負荷により有効弁口面積が増加する (2013)
  • Author(s): 宇賀小百合、日髙貴之、宇都宮裕人、木原康樹、内田直里、末田泰二郎
  • Organizer: 日本超音波医学会第49回中国地方会第12回中国地方会講習会
  • Place of Presentation: 鳥取
  • Year and Date: 20130928-20130928
• [Presentation] Regulation of eNOS mRNA stability via ROCK2-mediated eEF1A1 phosphorylation. (2013)
  • Author(s): 野間玄督、木原康樹、東幸仁
  • Organizer: 第21回日本血管生物医学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 20130926-20130926
• [Presentation] 冠動脈CTによる虚血性心疾患の予後評価－我が国における大規模前向き試験－ (2013)
  • Author(s): 山本秀也、木原康樹
  • Organizer: 第61回日本心臓病学会学術集会
  • Place of Presentation: 熊本
  • Year and Date: 20130920-20130920
• [Presentation] 心肺停止蘇生後症例における緊急冠動脈ＣＴの活用－320の列型ＣＴを用いた試み－ (2013)
  • Author(s): 北川知郎、山本秀也、土肥由裕、栗栖智、中野由紀子、木原康樹
  • Organizer: 第61回日本心臓病学会学術集会
  • Place of Presentation: 熊本
  • Year and Date: 20130920-20130920
• [Presentation] 植込み型デバイスに記録される胸郭インピーダンスと心不全治療後の体重変化との関連 (2013)
  • Author(s): 小田登、中野由紀子、高永甲有司、本田秀子、三浦勝也、山根彩、住元庸二、中野良規、香川英介、佐々木正太、加藤雅也、土手慶五、木原康樹
  • Organizer: 第61回日本心臓病学会学術集会
  • Place of Presentation: 熊本
  • Year and Date: 20130920-20130920
• [Presentation] 広島県内の急性期医療機関における、ＢＮＰまたはＮＴ－ｐｒｏＢＮＰ高値患者数と入院率、再入院率の実態 (2013)
  • Author(s): 小田登、池永寛樹、宇都宮裕人、石橋堅、光波直也、土肥由裕、日髙貴之、栗栖智、中野由紀子、石田隆史、山本秀也、水川真理子、木原康樹
  • Organizer: 第61回日本心臓病学会学術集会
  • Place of Presentation: 熊本
  • Year and Date: 20130920-20130920
• [Presentation] 心不全センターにおける慢性心不全患者に対する多職腫チームアプローチ (2013)
  • Author(s): 水川真理子、北川知郎、木阪智彦、山本秀也、木下弘喜、内田直里、中村マリ子、下村麻規子、田代尚範、天野加奈子、櫻下弘志、増田有紀、吉岡徹典、木原康樹
  • Organizer: 第61回日本心臓病学会学術集会
  • Place of Presentation: 熊本
  • Year and Date: 20130920-20130920
• [Presentation] 心筋血流定量解析ソフトHeart Score ViewとQuantitative Perfusion SPECTのスコアリング精度の比較検討 (2013)
  • Author(s): 岩崎年高、栗栖智、下永貴司、對馬浩、光波直也、石橋堅、土肥由裕、木原康樹
  • Organizer: 第61回日本心臓病学会学術集会
  • Place of Presentation: 熊本
  • Year and Date: 20130920-20130920
• [Presentation] 低体温療法を行った院内と院外心肺停止患者の特徴 (2013)
  • Author(s): 香川英介、土手慶五、加藤雅也、佐々木正太、小田登、中野良規、住元庸二、本田秀子、高永甲有司、木原康樹
  • Organizer: 第61回日本心臓病学会学術集会
  • Place of Presentation: 熊本
  • Year and Date: 20130920-20130920
• [Presentation] Detection of developing pulmonary vasculopathy in the early stage of pulmonary arterial hypertension with non- invasive (2013)
  • Author(s): 木下弘喜、土肥由裕、佐田良治、木原康樹
  • Organizer: 第13回国際エンドセリン学会
  • Place of Presentation: 東京
  • Year and Date: 20130908-20130911
• [Presentation] LAD stent edgeがLCX ostiumにかかっていたためにLMTへの治療に難渋した一例 (2013)
  • Author(s): 渡邊紀晶、光波直也、東昭史、下永貴司、檜垣忠直、岩崎年高、宇都宮裕人、石橋堅、土肥由裕、栗栖智、木原康樹
  • Organizer: 第20回日本心血管インタ－ベンション治療学会中国・四国地方会
  • Place of Presentation: 岡山
  • Year and Date: 20130907-20130907
• [Presentation] 血栓吸引デバイスの使用法について考えさせられた一例 (2013)
  • Author(s): 檜垣忠直、光波直也、渡邊紀晶、東昭史、下永貴司、岩崎年高、宇都宮裕人、石橋堅、土肥由裕、栗栖智、木原康樹
  • Organizer: 第20回日本心血管インターベンション治療学会中国・四国地方会
  • Place of Presentation: 岡山
  • Year and Date: 20130907-20130907
• [Presentation] Adaptive-servo ventilation may be a new additional therapy to improve symptoms and cardiac function for patients with chronic heart failure regardless of accompanying sleep disordered breathing. (2013)
  • Author(s): S.Momomura,Y.Seino,Y.Kihara,H.Adachi,Y.Yasumura,H.Yokoyama,The SAVIOR-R investigators.
  • Organizer: 欧州心臓学会会議(ESC 2013)
  • Place of Presentation: Amsterdam,The Netherlands.
  • Year and Date: 20130831-20130904
  • Invited
• [Presentation] Prognostic Value of Coronary Artery Calcium and Epicardial Adipose Tissue Assessed by Non-contrast Computed Tomography (2013)
  • Author(s): Yamamoto H, Kunita E, Toshiro K, Utsunomiya H, Urabe U, Tsushima H, Kihara Y, Budoff MJ
  • Organizer: The 8th Scientific Sessions, Society of Cardiovascular Computed Tomography
  • Place of Presentation: Montréal, Canada,
  • Year and Date: 20130719-20130719
• [Presentation] 即戦力UP! これであなたの検査が変わる!!心不全治療の最前線 (2013)
  • Author(s): 木原康樹
  • Organizer: JSS中国第14回地方会学術集会
  • Place of Presentation: 広島
  • Year and Date: 20130714-20130714
  • Invited
• [Presentation] Is transfemoral coronary intervention clean enough? (2013)
  • Author(s): K.Ishibashi,S.Kurisu,T.Shimonaga,T.Iwasaki,H.Utsunomiya,N.Mitsuba,Y.Dohi,H.Yamamoto,Y.Kihara
  • Organizer: 第22回日本心血管インターベンション治療学会学術集会（CVIT2013）
  • Place of Presentation: 兵庫
  • Year and Date: 20130713-20130713
• [Presentation] Ｕｎｉｎｔｅｒｒｕｐｔｅｄ Ａｎticoagulation with Warfarin or Dabigatran for Periprocedural Anticoagulation in Patients Undergoing Ablation for Atrial Fibrillation. (2013)
  • Author(s): Y.Nakano,N.Oda,K.Kajihara,T.Tokuyama,M.Fujiwara,Y.Watanabe,H.Kawazoe,H.Ikenaga,A.Sairaku,Y.Uchimura,C.Motoda,Y.Kihara
  • Organizer: The 28th Annual Meeting of the Japanese Heart Rhythm Society
  • Place of Presentation: 東京
  • Year and Date: 20130704-20130706
• [Presentation] The Periprocedural Coagulability in Patients Undergoing Ablation of Atrial Fibrillation:Lessons from a Periablation Anticoagulation Strategy of a Brief Withdrawal of Warfarin without Heparin Bridging. (2013)
  • Author(s): A.Sairaku,Y.Yoshida,M.Ando,H.Kamiya,H.Hirayama,Y.Nakano,Y.Kihara.
  • Organizer: The 28th Annual Meeting of the Japanese Heart Rhythm Society
  • Place of Presentation: 東京
  • Year and Date: 20130704-20130706
• [Presentation] Outcomes of Catheter Ablation for Atrial Fibrillation in Patients with Hypertrophic Cardiomyopath. (2013)
  • Author(s): H.Ikenaga,Y.Nakano,N.Oda,K.Kajihara,T.Tokuyama,M.Fujiwara,Y.Watanabe,Y.Kihara.
  • Organizer: The 28th Annual Meeting of the Japanese Heart Rhythm Society
  • Place of Presentation: 東京
  • Year and Date: 20130704-20130706
• [Presentation] Analysis of Left Atrial Mechanical Functions and Electrophysiological Paraneters Using Three-Dimensional Speckle Tracking Echocardiography in Patients with Paroxysmal Atrial Fibrillation. (2013)
  • Author(s): Y.Watanabe,Y.Nakano,H.Ikenaga,M.Fujiwara,A.Motoda,T.Tokuyama,K.Kajihara,N.Oda,Y.Kihara.
  • Organizer: The 28th Annual Meeting of the Japanese Heart Rhythm Society
  • Place of Presentation: 東京
  • Year and Date: 20130704-20130706
• [Presentation] 脾臓摘出後に発症した慢性血栓閉塞性肺高血圧症（CTEPH)の一例 (2013)
  • Author(s): 三吉貴大、檜垣忠直、土肥由裕、木原康樹
  • Organizer: 第102回 日本循環器学会中国・四国合同地方会
  • Place of Presentation: 香川
  • Year and Date: 20130510-20130511
• [Presentation] 甲状腺機能低下症により心嚢液貯留と左室収縮低下を来した1例 (2013)
  • Author(s): 石橋堅、池永寛樹、宇都宮裕人、光波直也、小田登、土肥由裕、日高貴之、栗栖智、中野由紀子、山本秀也、石田隆史、木原康樹
  • Organizer: 第102回 日本循環器学会中国・四国合同地方会
  • Place of Presentation: 香川
  • Year and Date: 20130510-20130511
• [Presentation] 劇症型心筋炎にPacingは必要か？ (2013)
  • Author(s): 小山田直子、木原康樹、土肥由裕、川副宏、岩本明倫
  • Organizer: 第102回 日本循環器学会中国・四国合同地方会
  • Place of Presentation: 香川
  • Year and Date: 20130510-20130511
• [Book] 循環器疾患最新の治療 循環器領域における最近の注目エビデンス 慢性心不全のエビデンス (2014)
  • Author(s): 木阪智彦、木原康樹
  • Total Pages: P.446-450
  • Publisher: 南江堂
• [Book] 医学と薬学 心房細動・心房粗動 (2013)
  • Author(s): 中野由紀子、木原康樹
  • Total Pages: vol69 No4 P595-608
  • Publisher: 自然科学者（株）
• [Book] 今日の治療指針 2013年版 拘束型心筋症、不整脈原性（催不整脈性）右室心筋症 (2013)
  • Author(s): 木原康樹
  • Total Pages: P.392-393
  • Publisher: 医学書院
• [Remarks] 広島大学循環器内科学ホームページ
  • URL: http://home.hiroshima-u.ac.jp/cardio/