Rapid detection of CYP2C19 reduced-function gene polymorphism and the establishment of optimal medical therapy in patients with acute coronary syndrome

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591062
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Kumamoto University
• Principal Investigator: KAIKITA Koichi 熊本大学, 医学部附属病院, 講師 (30346978)
• Research Collaborator: YOSHIMURA Hiromi 熊本大学, 医学教育部
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 循環器・高血圧 / 遺伝子

Outline of Final Research Achievements

In patients with acute myocardial infarction undergoing emergent percutaneous coronary intervention, we investigated CYP2C19 gene variants by using Spartan RX DNA testing system, determined the dose of antiplatelet agents, and then examined the relation between on-clpidogrel platelet aggregation, the related biomarkers and the prognosis in those patients. We aimed for 150 patients as a prospective interventional study, and enrolled 108 patients as of April 2015. We plan to start data analysis after the measurement of the above-mentioned biomarkers is finished in all enrolled patients.

Free Research Field

医歯薬学