mechanisms of vascular endothelial function in metabolic syndrome subjects and novel therapeutic approach

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591063
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: University of the Ryukyus
• Principal Investigator: YAMAKAWA Ken 琉球大学, 医学(系)研究科(研究院), 講師 (00363664)
• Co-Investigator(Kenkyū-buntansha): HIGA Moritake 琉球大学, 大学院医学研究科, 非常勤講師 (70347152) ; SHIMABUKURO Michio 徳島大学, 大学院ヘルスバイオサイエンス研究部, 特任教授 (60271144) ; MASUZAKI Hiroaki 琉球大学, 大学院医学研究科, 教授 (00291899)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: メタボリックシンドローム / 動脈硬化 / 血管内皮機能

Outline of Final Research Achievements

Vascular endothelial dysfunction is an early marker for atherosclerosis. We investigated the effect of metabolic stress on vascular endothelial function in human and/or experimental animas. We found brown rice improve vascular endothelial function of metabolic syndrome subjects compared to white rice as well as their insulin sensitivity. Gamma-oryzanol, a major content of brown rice, improve glucose metabolism, reduce hypothalamic ER stress, and, consequently, attenuate the preference for dietary fat in mice. Xanthine oxidase is one of major source of reactive oxygen species in metabolic syndrome subjects. We reported that inhibition of xanthine oxidase reduces oxidative stress and improves vascular endothelial dysfunction in metabolic stress mouse. Xanthine oxidase inhibitor, such as allopurinol and febuxostat may be effective to suppress progression of atherosclerosis.

Free Research Field

内科