The effect of cardiac rehabilitation on the myokines in patients with heart failura

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591066
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Osaka City University
• Principal Investigator: YOSHIYAMA Minoru 大阪市立大学, 医学(系)研究科(研究院), 教授 (30240956)
• Co-Investigator(Renkei-kenkyūsha): IZUMI Yasukatsu 大阪市立大学大学, 医学研究科, 准教授 (10347495) ; NAKAMURA Yasuhiro 大阪市立大学, 医学研究科, 登録医 (50457991)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 心臓リハビリテーション / マイオカイン / 心血管保護効果 / 運動耐容能

Outline of Final Research Achievements

Exercise tolerance, not left ventricular ejection fraction, was important prognostic indicator for patients with chronic heart failure. Cardiac rehabilitation can prevent major cardiac adverse events. However, this mechanism is still unknown. Skeletal muscle has recently been identified as an organ that produces and releases cytokines, named “myokines.” We investigated whether serum brain derived neurotropic factor (BDNF) level or irisin, which is one of myokines, level at discharge could predict the prognosis in patients with heart failure (HF). This study consisted of patients who were hospitalized for worsening heart failure and had cardiac rehabilitation at least 1 week. We measured serum BNDF, and irisin. One-year follow-up was completed in all of the patients. Kaplan-Meier analysis demonstrated that the event free rate was decreased in the low BDNF or irisin group. Myokines level at discharge may be a useful biomarker for the prognosis in patients with HF.

Free Research Field

循環器内科学