Effectiveness of Erythropoietin Administration on Coronary Circulation in Patients After Acute Myocardial Infarction

2015 Fiscal Year Final Research Report

• Project/Area Number: 24591067
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Osaka Kyoiku University (2015); Wakayama Medical University (2012-2014)
• Principal Investigator: Hirata Kumiko 大阪教育大学, 教育学部, 教授 (10382152)
• Co-Investigator(Kenkyū-buntansha): AKASAKA Takashi 和歌山県立医科大学, 循環器内科, 教授 (70322584) ; IMANISHI Toshio 日高総合病院, 副院長 (00285389) ; ORII Makoto 和歌山県立医科大学, 循環器内科, 助教 (70508986)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 冠循環

Outline of Final Research Achievements

Background: Erythropoietin(EPO) has been found to have anti-apoptotic and tissue protective effects on the myocardium. The aim of the present study was to assess the effect of EPO administration on coronary circulation in patients with acute myocardial infarction(AMI). Methods and Results: Sixty-one patients admitted with AMI were randomly assigned to 2 groups (29 control and 32 EPO groups), and given single dose intravenous administration of EPO or saline. Coronary flow reserve(CFR) was measured 1 week, 1 month and 8 months after AMI. Cardiac MRI was also performed 1 month after AMI to assess transmural extent of infarction. CFR improved significantly in EPO group after 8 months after AMI. The control group had a tendency of greater transmural extent of infarction than that of EPO group. Conclusions: EPO administration could have a favorable effect on coronary circulation and a preventive effect on transmural extension of infarction in patients after myocardial infarction.

Free Research Field

循環器内科